A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate
ABSTRACT Introduction Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failu...
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| Format: | Article |
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Wiley
2024-11-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70136 |
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| author | Abubakar Nazir Olivier Uwishema Sanobar Shariff William Xochitun Gopar Franco Noha El Masri Nitsuh Dejene Ayele Isabelle Munyangaju Fatima Esam Alzain Magda Wojtara |
| author_facet | Abubakar Nazir Olivier Uwishema Sanobar Shariff William Xochitun Gopar Franco Noha El Masri Nitsuh Dejene Ayele Isabelle Munyangaju Fatima Esam Alzain Magda Wojtara |
| author_sort | Abubakar Nazir |
| collection | DOAJ |
| description | ABSTRACT Introduction Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failure, myocardial infarction, and arrhythmias have been widely researched. Materials and Methods The present study provides an overview of existing evidence regarding miRNAs' role in cardiovascular disease pathogenesis. Furthermore, the study examines current state‐of‐the‐art technologies used in the study of miRNAs in cardiovascular disease. As a final point, we examine how miRNAs may serve as disease biomarkers, therapeutic targets, and prognostic indicators. Results In cardiology, microRNAs, small noncoding RNA molecules, are crucial to the posttranscriptional regulation of genes. Their role in regulating cardiac cell differentiation and maturation is critical during the development of the heart. They maintain the cardiac function of an adult heart by contributing to its electrical and contractile activity. By binding to messenger RNA molecules, they inhibit protein translation or degrade mRNA. Several cardiovascular diseases are associated with dysregulation of miRNAs, including arrhythmias, hypertension, atherosclerosis, and heart failure. miRNAs can be used as biomarkers to diagnose and predict diseases as well as therapeutic targets. A variety of state‐of‐the‐art technologies have aided researchers in discovering, profiling, and analyzing miRNAs, including microarray analysis, next‐generation sequencing, and others. Conclusion Developing new diagnostics and therapeutic approaches is becoming more feasible as researchers refine their understanding of miRNA function. Ultimately, this will reduce the burden of cardiovascular disease around the world. |
| format | Article |
| id | doaj-art-797bf3ab9a2b41f0b23236f34222913b |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-797bf3ab9a2b41f0b23236f34222913b2025-08-20T02:48:41ZengWileyHealth Science Reports2398-88352024-11-01711n/an/a10.1002/hsr2.70136A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular FateAbubakar Nazir0Olivier Uwishema1Sanobar Shariff2William Xochitun Gopar Franco3Noha El Masri4Nitsuh Dejene Ayele5Isabelle Munyangaju6Fatima Esam Alzain7Magda Wojtara8Department of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaDepartment of Medicine Oli Health Magazine Organization, Research and Education Kigali RwandaABSTRACT Introduction Cardiovascular diseases contribute significantly to global morbidity and mortality. MicroRNAs are crucial in the development and progression of these diseases by regulating gene expression in various cells and tissues. Their roles in conditions like atherosclerosis, heart failure, myocardial infarction, and arrhythmias have been widely researched. Materials and Methods The present study provides an overview of existing evidence regarding miRNAs' role in cardiovascular disease pathogenesis. Furthermore, the study examines current state‐of‐the‐art technologies used in the study of miRNAs in cardiovascular disease. As a final point, we examine how miRNAs may serve as disease biomarkers, therapeutic targets, and prognostic indicators. Results In cardiology, microRNAs, small noncoding RNA molecules, are crucial to the posttranscriptional regulation of genes. Their role in regulating cardiac cell differentiation and maturation is critical during the development of the heart. They maintain the cardiac function of an adult heart by contributing to its electrical and contractile activity. By binding to messenger RNA molecules, they inhibit protein translation or degrade mRNA. Several cardiovascular diseases are associated with dysregulation of miRNAs, including arrhythmias, hypertension, atherosclerosis, and heart failure. miRNAs can be used as biomarkers to diagnose and predict diseases as well as therapeutic targets. A variety of state‐of‐the‐art technologies have aided researchers in discovering, profiling, and analyzing miRNAs, including microarray analysis, next‐generation sequencing, and others. Conclusion Developing new diagnostics and therapeutic approaches is becoming more feasible as researchers refine their understanding of miRNA function. Ultimately, this will reduce the burden of cardiovascular disease around the world.https://doi.org/10.1002/hsr2.70136cardiac diseasesgene expressionmiRNAvascular diseases |
| spellingShingle | Abubakar Nazir Olivier Uwishema Sanobar Shariff William Xochitun Gopar Franco Noha El Masri Nitsuh Dejene Ayele Isabelle Munyangaju Fatima Esam Alzain Magda Wojtara A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate Health Science Reports cardiac diseases gene expression miRNA vascular diseases |
| title | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate |
| title_full | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate |
| title_fullStr | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate |
| title_full_unstemmed | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate |
| title_short | A Thorough Navigation of miRNA's Blueprint in Crafting Cardiovascular Fate |
| title_sort | thorough navigation of mirna s blueprint in crafting cardiovascular fate |
| topic | cardiac diseases gene expression miRNA vascular diseases |
| url | https://doi.org/10.1002/hsr2.70136 |
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