Defining Nocturnal Polyuria in Adolescents
Nocturnal polyuria (NP) is a leading cause of nocturia in adults. While diagnostic criteria for NP have been established in adult men, they have not been validated in other demographic groups including women, adolescents, and children, and little is known about appropriate reference values in these...
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Elsevier
2025-03-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772973725000013 |
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| author | Tasmia Promi Anthony Brooks Gulzhan Tologonova Marie-Claire Roberts Sarita Dhuper Meseret Tena Oluwatoyin Bamgbola Monique Hanono Jeffrey P. Weiss Karel Everaert Tine DeBacker Thomas F. Monaghan Louis Salciccioli Stephen Wadowski Elka Jacobson-Dickman Jason M. Lazar |
| author_facet | Tasmia Promi Anthony Brooks Gulzhan Tologonova Marie-Claire Roberts Sarita Dhuper Meseret Tena Oluwatoyin Bamgbola Monique Hanono Jeffrey P. Weiss Karel Everaert Tine DeBacker Thomas F. Monaghan Louis Salciccioli Stephen Wadowski Elka Jacobson-Dickman Jason M. Lazar |
| author_sort | Tasmia Promi |
| collection | DOAJ |
| description | Nocturnal polyuria (NP) is a leading cause of nocturia in adults. While diagnostic criteria for NP have been established in adult men, they have not been validated in other demographic groups including women, adolescents, and children, and little is known about appropriate reference values in these populations. Accordingly, the present study aimed to determine an hourly nocturnal urine production (NUP) rate in adolescents most predictive of the presence of nocturia. We analyzed prospectively collected data of 100 male and female adolescents aged 10-18 years. All subjects completed nocturnal voiding diaries and significant nocturia was defined as ≥1 or more voids per night. Receiver operating characteristic (ROC) curves were used to test the performance of different NUP values in predicting nocturia. On ROC, the area under curve (AUC) was 0.85. On multivariable logistic regression with variables of sex, obesity, and elevated blood pressure, adding NUP as a categorical variable maximally increased the predictive value of the model upon utilizing a cutoff of 50 ml/h, increasing the R2 from 0.491 to 0.683. A NUP >50 ml/h had a sensitivity of 62.2% and a specificity of 96.4% in predicting nocturia. A cut-off value of NUP >50 ml/h may be relevant to the clinical management of adolescents with nocturia. |
| format | Article |
| id | doaj-art-7978bab6d7d049248357efb1fb9e4feb |
| institution | Kabale University |
| issn | 2772-9737 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Continence |
| spelling | doaj-art-7978bab6d7d049248357efb1fb9e4feb2025-02-08T05:01:46ZengElsevierContinence2772-97372025-03-0113101744Defining Nocturnal Polyuria in AdolescentsTasmia Promi0Anthony Brooks1Gulzhan Tologonova2Marie-Claire Roberts3Sarita Dhuper4Meseret Tena5Oluwatoyin Bamgbola6Monique Hanono7Jeffrey P. Weiss8Karel Everaert9Tine DeBacker10Thomas F. Monaghan11Louis Salciccioli12Stephen Wadowski13Elka Jacobson-Dickman14Jason M. Lazar15Division of Cardiovascular Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USA; Correspondence to: State University of New York Downstate Health Sciences University, Division of Cardiovascular Medicine, 450 Clarkson Avenue, Box 1199, Brooklyn, 11203-2098, NY, USA.Department of Urology, Main Line Health, Bryn Mawr, PA, USADivision of Cardiovascular Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USACollege of Nursing, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Urology, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Human Structure and Repair, Ghent University Hospital, Ghent, BelgiumDepartment of Internal Medicine and Pediatrics, Ghent University Hospital, Ghent, BelgiumDepartment of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USADivision of Cardiovascular Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADepartment of Pediatrics, State University of New York Downstate Health Sciences University, Brooklyn, NY, USADivision of Cardiovascular Medicine, State University of New York Downstate Health Sciences University, Brooklyn, NY, USANocturnal polyuria (NP) is a leading cause of nocturia in adults. While diagnostic criteria for NP have been established in adult men, they have not been validated in other demographic groups including women, adolescents, and children, and little is known about appropriate reference values in these populations. Accordingly, the present study aimed to determine an hourly nocturnal urine production (NUP) rate in adolescents most predictive of the presence of nocturia. We analyzed prospectively collected data of 100 male and female adolescents aged 10-18 years. All subjects completed nocturnal voiding diaries and significant nocturia was defined as ≥1 or more voids per night. Receiver operating characteristic (ROC) curves were used to test the performance of different NUP values in predicting nocturia. On ROC, the area under curve (AUC) was 0.85. On multivariable logistic regression with variables of sex, obesity, and elevated blood pressure, adding NUP as a categorical variable maximally increased the predictive value of the model upon utilizing a cutoff of 50 ml/h, increasing the R2 from 0.491 to 0.683. A NUP >50 ml/h had a sensitivity of 62.2% and a specificity of 96.4% in predicting nocturia. A cut-off value of NUP >50 ml/h may be relevant to the clinical management of adolescents with nocturia.http://www.sciencedirect.com/science/article/pii/S2772973725000013Nocturnal polyuriaNocturiaAdolescentsNocturnal urine productionPediatric urology |
| spellingShingle | Tasmia Promi Anthony Brooks Gulzhan Tologonova Marie-Claire Roberts Sarita Dhuper Meseret Tena Oluwatoyin Bamgbola Monique Hanono Jeffrey P. Weiss Karel Everaert Tine DeBacker Thomas F. Monaghan Louis Salciccioli Stephen Wadowski Elka Jacobson-Dickman Jason M. Lazar Defining Nocturnal Polyuria in Adolescents Continence Nocturnal polyuria Nocturia Adolescents Nocturnal urine production Pediatric urology |
| title | Defining Nocturnal Polyuria in Adolescents |
| title_full | Defining Nocturnal Polyuria in Adolescents |
| title_fullStr | Defining Nocturnal Polyuria in Adolescents |
| title_full_unstemmed | Defining Nocturnal Polyuria in Adolescents |
| title_short | Defining Nocturnal Polyuria in Adolescents |
| title_sort | defining nocturnal polyuria in adolescents |
| topic | Nocturnal polyuria Nocturia Adolescents Nocturnal urine production Pediatric urology |
| url | http://www.sciencedirect.com/science/article/pii/S2772973725000013 |
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