Comparative effectiveness of monotherapy vs. combination therapy for postoperative central nervous system infections in neurosurgical patients: a retrospective cohort study

Comparative effectiveness of monotherapy vs. combination therapy for postoperative central nervous system infections in neurosurgical patients: a retrospective cohort study

Abstract Background Although clinical guidelines recommend vancomycin-based combination therapy for patients with postoperative intracranial infections in neurosurgery, the trend of global bacterial resistance and the management of antimicrobial agents have made monotherapy a common treatment option...

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Bibliographic Details
Main Authors:	Muyun Li, Wei Meng, Linna An, Xiaoqi Lin, Shangjie Yang, Qiang Fu, Qiuxia Shi, Dongfeng Li, Jie Wang, Jianhua Wang, Yubo Wang
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Series:	BMC Infectious Diseases
Subjects:	Central nervous system infections Single-Drug therapy Vancomycin combination therapy Antibiotic resistance Neurosurgery
Online Access:	https://doi.org/10.1186/s12879-025-11031-0
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