Cystamine reduces neurodegeneration and epileptogenesis following soman-induced status epilepticus in rats

Cystamine reduces neurodegeneration and epileptogenesis following soman-induced status epilepticus in rats

Acute exposure to a seizure-inducing dose of an organophosphorus nerve agent inhibits acetylcholinesterase, leading to pharmacoresistance if benzodiazepine treatment is delayed. Following soman-induced status epilepticus (SE) in rats, prolonged seizure is associated with severe and widespread neurod...

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Bibliographic Details
Main Authors: Abiel K. Biney, Caroline R. Schultz, Michael F. Stone, Donna A. Nguyen, Annie Wang, Marcio de Araujo Furtado, Lucille A. Lumley
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Experimental Biology and Medicine
Subjects:
organophosphorus nerve agents
seizures
status epilepticus
cystamine
neuroprotection
Online Access:https://www.ebm-journal.org/articles/10.3389/ebm.2025.10598/full
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