Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo
Microglia-induced maladaptive plasticity is being recognized as a major cause of deleterious self-sustaining pathological processes that occur in neurodegenerative and neuroinflammatory diseases. Microglia, the primary homeostatic guardian of the central nervous system, exert critical functions both...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2015/135342 |
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| author | Stefano Morara Anna Maria Colangelo Luciano Provini |
| author_facet | Stefano Morara Anna Maria Colangelo Luciano Provini |
| author_sort | Stefano Morara |
| collection | DOAJ |
| description | Microglia-induced maladaptive plasticity is being recognized as a major cause of deleterious self-sustaining pathological processes that occur in neurodegenerative and neuroinflammatory diseases. Microglia, the primary homeostatic guardian of the central nervous system, exert critical functions both during development, in neural circuit reshaping, and during adult life, in the brain physiological and pathological surveillance. This delicate critical role can be disrupted by neural, but also peripheral, noxious stimuli that can prime microglia to become overreactive to a second noxious stimulus or worsen underlying pathological processes. Among regulators of microglia, neuropeptides can play a major role. Their receptors are widely expressed in microglial cells and neuropeptide challenge can potently influence microglial activity in vitro. More relevantly, this regulator activity has been assessed also in vivo, in experimental models of brain diseases. Neuropeptide action in the central nervous system has been associated with beneficial effects in neurodegenerative and neuroinflammatory pathological experimental models. This review describes some of the mechanisms of the microglia maladaptive plasticity in vivo and how neuropeptide activity can represent a useful therapeutical target in a variety of human brain pathologies. |
| format | Article |
| id | doaj-art-7969967bb75348fbb66da329b5021886 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-7969967bb75348fbb66da329b50218862025-08-20T03:35:23ZengWileyNeural Plasticity2090-59041687-54432015-01-01201510.1155/2015/135342135342Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In VivoStefano Morara0Anna Maria Colangelo1Luciano Provini2Neuroscience Institute (CNR), Via Vanvitelli 32, 20129 Milano, ItalyLaboratory of Neuroscience “R. Levi-Montalcini”, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, ItalyDepartment of BIOMETRA, University of Milano, Via Vanvitelli 32, 20129 Milano, ItalyMicroglia-induced maladaptive plasticity is being recognized as a major cause of deleterious self-sustaining pathological processes that occur in neurodegenerative and neuroinflammatory diseases. Microglia, the primary homeostatic guardian of the central nervous system, exert critical functions both during development, in neural circuit reshaping, and during adult life, in the brain physiological and pathological surveillance. This delicate critical role can be disrupted by neural, but also peripheral, noxious stimuli that can prime microglia to become overreactive to a second noxious stimulus or worsen underlying pathological processes. Among regulators of microglia, neuropeptides can play a major role. Their receptors are widely expressed in microglial cells and neuropeptide challenge can potently influence microglial activity in vitro. More relevantly, this regulator activity has been assessed also in vivo, in experimental models of brain diseases. Neuropeptide action in the central nervous system has been associated with beneficial effects in neurodegenerative and neuroinflammatory pathological experimental models. This review describes some of the mechanisms of the microglia maladaptive plasticity in vivo and how neuropeptide activity can represent a useful therapeutical target in a variety of human brain pathologies.http://dx.doi.org/10.1155/2015/135342 |
| spellingShingle | Stefano Morara Anna Maria Colangelo Luciano Provini Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo Neural Plasticity |
| title | Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo |
| title_full | Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo |
| title_fullStr | Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo |
| title_full_unstemmed | Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo |
| title_short | Microglia-Induced Maladaptive Plasticity Can Be Modulated by Neuropeptides In Vivo |
| title_sort | microglia induced maladaptive plasticity can be modulated by neuropeptides in vivo |
| url | http://dx.doi.org/10.1155/2015/135342 |
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