Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.
Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the...
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031369&type=printable |
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| author | Vesna Boraska Aaron Day-Williams Christopher S Franklin Katherine S Elliott Kalliope Panoutsopoulou Ioanna Tachmazidou Eva Albrecht Stefania Bandinelli Lawrence J Beilin Murielle Bochud Gemma Cadby Florian Ernst David M Evans Caroline Hayward Andrew A Hicks Jennifer Huffman Cornelia Huth Alan L James Norman Klopp Ivana Kolcic Zoltán Kutalik Debbie A Lawlor Arthur W Musk Marina Pehlic Craig E Pennell John R B Perry Annette Peters Ozren Polasek Beate St Pourcain Susan M Ring Erika Salvi Sabine Schipf Jan A Staessen Alexander Teumer Nicholas Timpson Veronique Vitart Nicole M Warrington Hanieh Yaghootkar Tatijana Zemunik Lina Zgaga Ping An Verneri Anttila Ingrid B Borecki Jostein Holmen Ioanna Ntalla Aarno Palotie Kirsi H Pietiläinen Juho Wedenoja Bendik S Winsvold George V Dedoussis Jaakko Kaprio Michael A Province John-Anker Zwart Michel Burnier Harry Campbell Daniele Cusi George Davey Smith Timothy M Frayling Christian Gieger Lyle J Palmer Peter P Pramstaller Igor Rudan Henry Völzke H-Erich Wichmann Alan F Wright Eleftheria Zeggini |
| author_facet | Vesna Boraska Aaron Day-Williams Christopher S Franklin Katherine S Elliott Kalliope Panoutsopoulou Ioanna Tachmazidou Eva Albrecht Stefania Bandinelli Lawrence J Beilin Murielle Bochud Gemma Cadby Florian Ernst David M Evans Caroline Hayward Andrew A Hicks Jennifer Huffman Cornelia Huth Alan L James Norman Klopp Ivana Kolcic Zoltán Kutalik Debbie A Lawlor Arthur W Musk Marina Pehlic Craig E Pennell John R B Perry Annette Peters Ozren Polasek Beate St Pourcain Susan M Ring Erika Salvi Sabine Schipf Jan A Staessen Alexander Teumer Nicholas Timpson Veronique Vitart Nicole M Warrington Hanieh Yaghootkar Tatijana Zemunik Lina Zgaga Ping An Verneri Anttila Ingrid B Borecki Jostein Holmen Ioanna Ntalla Aarno Palotie Kirsi H Pietiläinen Juho Wedenoja Bendik S Winsvold George V Dedoussis Jaakko Kaprio Michael A Province John-Anker Zwart Michel Burnier Harry Campbell Daniele Cusi George Davey Smith Timothy M Frayling Christian Gieger Lyle J Palmer Peter P Pramstaller Igor Rudan Henry Völzke H-Erich Wichmann Alan F Wright Eleftheria Zeggini |
| author_sort | Vesna Boraska |
| collection | DOAJ |
| description | Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC. |
| format | Article |
| id | doaj-art-796957df8bba401b9cf154fcb070e256 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-796957df8bba401b9cf154fcb070e2562025-08-20T03:26:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3136910.1371/journal.pone.0031369Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.Vesna BoraskaAaron Day-WilliamsChristopher S FranklinKatherine S ElliottKalliope PanoutsopoulouIoanna TachmazidouEva AlbrechtStefania BandinelliLawrence J BeilinMurielle BochudGemma CadbyFlorian ErnstDavid M EvansCaroline HaywardAndrew A HicksJennifer HuffmanCornelia HuthAlan L JamesNorman KloppIvana KolcicZoltán KutalikDebbie A LawlorArthur W MuskMarina PehlicCraig E PennellJohn R B PerryAnnette PetersOzren PolasekBeate St PourcainSusan M RingErika SalviSabine SchipfJan A StaessenAlexander TeumerNicholas TimpsonVeronique VitartNicole M WarringtonHanieh YaghootkarTatijana ZemunikLina ZgagaPing AnVerneri AnttilaIngrid B BoreckiJostein HolmenIoanna NtallaAarno PalotieKirsi H PietiläinenJuho WedenojaBendik S WinsvoldGeorge V DedoussisJaakko KaprioMichael A ProvinceJohn-Anker ZwartMichel BurnierHarry CampbellDaniele CusiGeorge Davey SmithTimothy M FraylingChristian GiegerLyle J PalmerPeter P PramstallerIgor RudanHenry VölzkeH-Erich WichmannAlan F WrightEleftheria ZegginiBrachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p<0.05) in the age-adjusted strata for men and across both sexes. In this first GWAS meta-analysis for BC to date, we have not identified any genome-wide significant signals and do not observe robust association of previously established obesity loci with BC. Large-scale collaborations will be necessary to achieve higher power to detect loci underlying BC.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031369&type=printable |
| spellingShingle | Vesna Boraska Aaron Day-Williams Christopher S Franklin Katherine S Elliott Kalliope Panoutsopoulou Ioanna Tachmazidou Eva Albrecht Stefania Bandinelli Lawrence J Beilin Murielle Bochud Gemma Cadby Florian Ernst David M Evans Caroline Hayward Andrew A Hicks Jennifer Huffman Cornelia Huth Alan L James Norman Klopp Ivana Kolcic Zoltán Kutalik Debbie A Lawlor Arthur W Musk Marina Pehlic Craig E Pennell John R B Perry Annette Peters Ozren Polasek Beate St Pourcain Susan M Ring Erika Salvi Sabine Schipf Jan A Staessen Alexander Teumer Nicholas Timpson Veronique Vitart Nicole M Warrington Hanieh Yaghootkar Tatijana Zemunik Lina Zgaga Ping An Verneri Anttila Ingrid B Borecki Jostein Holmen Ioanna Ntalla Aarno Palotie Kirsi H Pietiläinen Juho Wedenoja Bendik S Winsvold George V Dedoussis Jaakko Kaprio Michael A Province John-Anker Zwart Michel Burnier Harry Campbell Daniele Cusi George Davey Smith Timothy M Frayling Christian Gieger Lyle J Palmer Peter P Pramstaller Igor Rudan Henry Völzke H-Erich Wichmann Alan F Wright Eleftheria Zeggini Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS ONE |
| title | Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. |
| title_full | Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. |
| title_fullStr | Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. |
| title_full_unstemmed | Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. |
| title_short | Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. |
| title_sort | genome wide association study to identify common variants associated with brachial circumference a meta analysis of 14 cohorts |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0031369&type=printable |
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