Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application
Abstract The tumor-immune response is mobilized to suppress tumorigenesis, while the immune microenvironment and lymph node microenvironment are formed gradually during tumor progression. In fact, tumor surface antigens are not easily recognized by antigen-presenting cells. So it is hard for the imm...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-04-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07544-w |
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| author | Yan Pan Hanqiong Zhou Zhenqiang Sun Yichen Zhu Zhe Zhang Jing Han Yang Liu Qiming Wang |
| author_facet | Yan Pan Hanqiong Zhou Zhenqiang Sun Yichen Zhu Zhe Zhang Jing Han Yang Liu Qiming Wang |
| author_sort | Yan Pan |
| collection | DOAJ |
| description | Abstract The tumor-immune response is mobilized to suppress tumorigenesis, while the immune microenvironment and lymph node microenvironment are formed gradually during tumor progression. In fact, tumor surface antigens are not easily recognized by antigen-presenting cells. So it is hard for the immune system to kill the newly formed tumor cells effectively. In a normal immune environment, immune function is always suppressed to maintain the stability of the body, and regulatory T cells play an important role in maintaining immune suppression. However, during tumorigenesis, the suppression of regulatory T cell immune functions is more likely to contribute to tumor cell proliferation and migration leading directly to tumor progression. Therefore, focusing on the role of regulatory T cells in tumor immunity could improve tumor immunotherapy outcomes in the clinic. Regulatory T cells are more mature in hematologic system tumors than in solid tumors. However, there are continuing efforts to apply regulatory T cells for immunotherapy in solid tumors. This review describes the role of regulatory T cells in solid tumor immunotherapy from the perspective of prognosis, immune microenvironment remodeling, and current clinical applications. This summary could help us better understand the mechanisms of regulatory T cells in solid tumor immunotherapy and further expand their clinical application. |
| format | Article |
| id | doaj-art-79674a4422e84556a4b95cc83d1b73ce |
| institution | DOAJ |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-79674a4422e84556a4b95cc83d1b73ce2025-08-20T03:10:10ZengNature Publishing GroupCell Death and Disease2041-48892025-04-0116111210.1038/s41419-025-07544-wRegulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical applicationYan Pan0Hanqiong Zhou1Zhenqiang Sun2Yichen Zhu3Zhe Zhang4Jing Han5Yang Liu6Qiming Wang7Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Colorectal Surgery, The First Affiliated Hospital of Zhengzhou UniversityDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalDepartment of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer HospitalAbstract The tumor-immune response is mobilized to suppress tumorigenesis, while the immune microenvironment and lymph node microenvironment are formed gradually during tumor progression. In fact, tumor surface antigens are not easily recognized by antigen-presenting cells. So it is hard for the immune system to kill the newly formed tumor cells effectively. In a normal immune environment, immune function is always suppressed to maintain the stability of the body, and regulatory T cells play an important role in maintaining immune suppression. However, during tumorigenesis, the suppression of regulatory T cell immune functions is more likely to contribute to tumor cell proliferation and migration leading directly to tumor progression. Therefore, focusing on the role of regulatory T cells in tumor immunity could improve tumor immunotherapy outcomes in the clinic. Regulatory T cells are more mature in hematologic system tumors than in solid tumors. However, there are continuing efforts to apply regulatory T cells for immunotherapy in solid tumors. This review describes the role of regulatory T cells in solid tumor immunotherapy from the perspective of prognosis, immune microenvironment remodeling, and current clinical applications. This summary could help us better understand the mechanisms of regulatory T cells in solid tumor immunotherapy and further expand their clinical application.https://doi.org/10.1038/s41419-025-07544-w |
| spellingShingle | Yan Pan Hanqiong Zhou Zhenqiang Sun Yichen Zhu Zhe Zhang Jing Han Yang Liu Qiming Wang Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application Cell Death and Disease |
| title | Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application |
| title_full | Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application |
| title_fullStr | Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application |
| title_full_unstemmed | Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application |
| title_short | Regulatory T cells in solid tumor immunotherapy: effect, mechanism and clinical application |
| title_sort | regulatory t cells in solid tumor immunotherapy effect mechanism and clinical application |
| url | https://doi.org/10.1038/s41419-025-07544-w |
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