Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play
MicroRNAs are key regulators of gene expression and play critical roles in both normal physiology and pathology. Recent research has demonstrated that these molecules are present in body fluids, such as serum, plasma, and urine, and can be readily measured using a variety of techniques. More importa...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/539680 |
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| _version_ | 1850219757164298240 |
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| author | Nikhil Sapre Luke A. Selth |
| author_facet | Nikhil Sapre Luke A. Selth |
| author_sort | Nikhil Sapre |
| collection | DOAJ |
| description | MicroRNAs are key regulators of gene expression and play critical roles in both normal physiology and pathology. Recent research has demonstrated that these molecules are present in body fluids, such as serum, plasma, and urine, and can be readily measured using a variety of techniques. More importantly, emerging evidence suggests that circulating or urine miRNAs are useful indicators of disease. Here, we consider the potential utility of such miRNAs as noninvasive biomarkers of prostate cancer, a disease that would benefit substantially from novel diagnostic and prognostic tools. The studies aimed at identifying diagnostic, prognostic, and/or predictive miRNAs for prostate cancer are summarised and reviewed. Finally, practical considerations that will influence the translation of this recent research into clinical implementation are discussed. |
| format | Article |
| id | doaj-art-7966fee6de7149b289b83fb3e0568ae5 |
| institution | OA Journals |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-7966fee6de7149b289b83fb3e0568ae52025-08-20T02:07:16ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/539680539680Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of PlayNikhil Sapre0Luke A. Selth1Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Level 5 Clinical Sciences Building, Parkville, Melbourne, VIC 3050, AustraliaDame Roma Mitchell Cancer Research Laboratories, The University of Adelaide, P.O. Box 14, Rundle Mall, Adelaide, SA 5000, AustraliaMicroRNAs are key regulators of gene expression and play critical roles in both normal physiology and pathology. Recent research has demonstrated that these molecules are present in body fluids, such as serum, plasma, and urine, and can be readily measured using a variety of techniques. More importantly, emerging evidence suggests that circulating or urine miRNAs are useful indicators of disease. Here, we consider the potential utility of such miRNAs as noninvasive biomarkers of prostate cancer, a disease that would benefit substantially from novel diagnostic and prognostic tools. The studies aimed at identifying diagnostic, prognostic, and/or predictive miRNAs for prostate cancer are summarised and reviewed. Finally, practical considerations that will influence the translation of this recent research into clinical implementation are discussed.http://dx.doi.org/10.1155/2013/539680 |
| spellingShingle | Nikhil Sapre Luke A. Selth Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play Prostate Cancer |
| title | Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play |
| title_full | Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play |
| title_fullStr | Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play |
| title_full_unstemmed | Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play |
| title_short | Circulating MicroRNAs as Biomarkers of Prostate Cancer: The State of Play |
| title_sort | circulating micrornas as biomarkers of prostate cancer the state of play |
| url | http://dx.doi.org/10.1155/2013/539680 |
| work_keys_str_mv | AT nikhilsapre circulatingmicrornasasbiomarkersofprostatecancerthestateofplay AT lukeaselth circulatingmicrornasasbiomarkersofprostatecancerthestateofplay |