Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex

Structure and stabilization of the antigenic glycoprotein building blocks of the New World mammarenavirus spike complex

ABSTRACT The spillover of New World (NW) arenaviruses from rodent reservoirs into human populations poses a continued risk to human health. NW arenaviruses present a glycoprotein (GP) complex on the envelope surface of the virion, which orchestrates host cell entry and is a key target of the immune...

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Bibliographic Details
Main Authors: Guido C. Paesen, Weng M. Ng, Simon Kimuda, Geoff Sutton, Katie J. Doores, Thomas A. Bowden
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
arenavirus
glycoprotein
structure
rational immunogen design
virus-host interactions
Online Access:https://journals.asm.org/doi/10.1128/mbio.01076-25
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