Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer

Anti-Tumor Efficacy of a Mesothelin-Based Nanovaccine in a KPC Orthotopic Mouse Model of Pancreatic Cancer

<b>Background/Objectives</b>: Immunotherapy has shown promising results in some cancers, but its efficacy remains limited in pancreatic ductal adenocarcinoma (PDAC). Vaccines in nanoparticle form (nanovaccines) can incorporate immunostimulating components to induce a potent immune respon...

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Bibliographic Details
Main Authors: Daniele P. Ferrari, Özmen Çobanoglu, Sana Sayedipour, Omar Luna, Sonia A. M. Ferkel, David Agorku, Yomkippur Perez, Luis J. Cruz, Fernando Albericio, François Trottein, Frauke Alves, Marietta Andrea Markus, Fernanda Ramos-Gomes
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
pancreatic cancer
immunotherapy
CD8<sup>+</sup> T cells
mesothelin
nanoparticles
Online Access:https://www.mdpi.com/2076-393X/13/3/314
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