Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications

Transduction of γδ T cells with Baboon envelope pseudotyped lentiviral vector encoding chimeric antigen receptors for translational and clinical applications

γδ T cells represent a promising cell platform for adoptive cell therapy. Their natural anti-tumor reactivity and HLA-independent target cell recognition make them an attractive platform for allogeneic adoptive immunotherapy clinical interventions. Initial clinical trials exploring allogeneic γδ T-c...

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Bibliographic Details
Main Authors: Lorraine Pinot, Aylin Saßor, Nina Möker, Congcong Zhang, Els Verhoeyen, José Villacorta Hidalgo, Rimas J. Orentas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
γδ T cells
chimeric antigen receptor
CAR gd T cells
lentiviral transduction
immunotherapy
allogeneic
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1548630/full
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