Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat.

Inter-relationship between testicular dysgenesis and Leydig cell function in the masculinization programming window in the rat.

The testicular dysgenesis syndrome (TDS) hypothesis proposes that maldevelopment of the testis, irrespective of cause, leads to malfunction of the somatic (Leydig, Sertoli) cells and consequent downstream TDS disorders. Studies in rats exposed in utero to di(n-butyl) phthalate (DBP) have strongly su...

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Bibliographic Details
Main Authors: Sander van den Driesche, Petros Kolovos, Sophie Platts, Amanda J Drake, Richard M Sharpe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0030111&type=printable
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