Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome
Background. CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis and the onset of acute coronary syndromes (ACS, including acute myocardial infarction (AMI) and unstable angina pectoris (UAP)). In addition to Th1, Th2, and Th17 cells, Th22 and Th9 subset...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/635672 |
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| _version_ | 1849409787526119424 |
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| author | Ying-zhong Lin Bang-wei Wu Zheng-de Lu Ying Huang Ying Shi Hao Liu Ling Liu Qiu-tang Zeng Xiang Wang Qing-wei Ji |
| author_facet | Ying-zhong Lin Bang-wei Wu Zheng-de Lu Ying Huang Ying Shi Hao Liu Ling Liu Qiu-tang Zeng Xiang Wang Qing-wei Ji |
| author_sort | Ying-zhong Lin |
| collection | DOAJ |
| description | Background. CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis and the onset of acute coronary syndromes (ACS, including acute myocardial infarction (AMI) and unstable angina pectoris (UAP)). In addition to Th1, Th2, and Th17 cells, Th22 and Th9 subsets have been identified in humans. In the present study, we investigated whether Th22 cells and Th9 cells are involved in the onset of ACS. Methods. The frequencies of Th22 and Th9 cells were detected using a flow cytometric analysis and their related cytokine and transcription factor were measured in the AMI, UAP, stable angina pectoris (SAP), and control groups. Results. The results revealed a significant increase in the peripheral Th22 number, AHR expression, and IL-22 levels in patients with ACS compared with those in the SAP and control groups. Although there was no difference in the peripheral Th9 number among the four groups, the PU.1 expression and IL-9 levels were significantly increased in patients with ACS compared with the SAP and control groups. Conclusions. Circulating Th22 and Th9 type responses may play a potential role in the onset of ACS symptom. |
| format | Article |
| id | doaj-art-79556b67e2e5430b92e07e87de14934c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-79556b67e2e5430b92e07e87de14934c2025-08-20T03:35:23ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/635672635672Circulating Th22 and Th9 Levels in Patients with Acute Coronary SyndromeYing-zhong Lin0Bang-wei Wu1Zheng-de Lu2Ying Huang3Ying Shi4Hao Liu5Ling Liu6Qiu-tang Zeng7Xiang Wang8Qing-wei Ji9Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Ultrasound, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaInstitute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaInstitute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, ChinaBackground. CD4+ T helper (Th) cells play critical roles in the development and progression of atherosclerosis and the onset of acute coronary syndromes (ACS, including acute myocardial infarction (AMI) and unstable angina pectoris (UAP)). In addition to Th1, Th2, and Th17 cells, Th22 and Th9 subsets have been identified in humans. In the present study, we investigated whether Th22 cells and Th9 cells are involved in the onset of ACS. Methods. The frequencies of Th22 and Th9 cells were detected using a flow cytometric analysis and their related cytokine and transcription factor were measured in the AMI, UAP, stable angina pectoris (SAP), and control groups. Results. The results revealed a significant increase in the peripheral Th22 number, AHR expression, and IL-22 levels in patients with ACS compared with those in the SAP and control groups. Although there was no difference in the peripheral Th9 number among the four groups, the PU.1 expression and IL-9 levels were significantly increased in patients with ACS compared with the SAP and control groups. Conclusions. Circulating Th22 and Th9 type responses may play a potential role in the onset of ACS symptom.http://dx.doi.org/10.1155/2013/635672 |
| spellingShingle | Ying-zhong Lin Bang-wei Wu Zheng-de Lu Ying Huang Ying Shi Hao Liu Ling Liu Qiu-tang Zeng Xiang Wang Qing-wei Ji Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome Mediators of Inflammation |
| title | Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome |
| title_full | Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome |
| title_fullStr | Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome |
| title_full_unstemmed | Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome |
| title_short | Circulating Th22 and Th9 Levels in Patients with Acute Coronary Syndrome |
| title_sort | circulating th22 and th9 levels in patients with acute coronary syndrome |
| url | http://dx.doi.org/10.1155/2013/635672 |
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