Serum IL-40 is elevated in systemic sclerosis and is linked to disease activity, gastrointestinal involvement, immune regulation and fibrotic processes

Serum IL-40 is elevated in systemic sclerosis and is linked to disease activity, gastrointestinal involvement, immune regulation and fibrotic processes

Abstract Background Interleukin 40 (IL-40) is a cytokine implicated in malignancies and rheumatic disorders. Its association with fibrotic mediators has been previously described. Since inflammation and fibrosis are hallmarks of systemic sclerosis (SSc), we aimed to analyze the role of IL-40 in SSc....

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Main Authors: Adéla Navrátilová, Sabína Oreská, Hana Wünsch, Klára Mocová, Ondřej Kodet, Marian Rybar, Glenda Alquicer, Aneta Prokopcová, Viktor Bečvář, Radim Bečvář, Aneta Jiránková, Anna Bobrová, Kateřina Bobrová, Karel Pavelka, Jiří Vencovský, Ladislav Šenolt, Lucie Andrés Cerezo, Michal Tomčík
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Arthritis Research & Therapy
Subjects:
Systemic sclerosis
Interleukin 40
Biomarkers
Online Access:https://doi.org/10.1186/s13075-025-03570-3
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