The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage
A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cortical, not subcortical, structures. However, among youth with...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187892932400152X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832591849410265088 |
|---|---|
| author | ET. Marcelle H. Yang JW. Cohen B. Ramphal D. Pagliaccio V. Rauh BS. Peterson F. Perera H. Andrews AG. Rundle J. Herbstman AE. Margolis |
| author_facet | ET. Marcelle H. Yang JW. Cohen B. Ramphal D. Pagliaccio V. Rauh BS. Peterson F. Perera H. Andrews AG. Rundle J. Herbstman AE. Margolis |
| author_sort | ET. Marcelle |
| collection | DOAJ |
| description | A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cortical, not subcortical, structures. However, among youth with low scores on reading tests who are living in the context of economic disadvantage, this brain network is actively engaged during reading, despite persistent reading problems. This finding suggests that other brain circuits may underlie reading in these youth. A hippocampal circuit is one likely candidate, as it has recently been shown to support domain-general processes like working memory (WM) that are also associated with reading. Given age-related increases in hippocampal volume, WM, and reading, and known associations between WM and reading, we hypothesized that hippocampal volume would be associated with reading via WM processes. Using a cross-sectional developmental design, we explored this in middle childhood (average age at MRI scan ∼10; N = 50) and adolescence (average age at MRI scan ∼17; N = 175). Results suggest that the hippocampus is a critical contributor to word reading in adolescents living in economically disadvantaged contexts, and that this operates through working memory processes. Such findings point to new targets for reading intervention in adolescents. |
| format | Article |
| id | doaj-art-794da448467649a69539139273875d92 |
| institution | Kabale University |
| issn | 1878-9293 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj-art-794da448467649a69539139273875d922025-01-22T05:41:18ZengElsevierDevelopmental Cognitive Neuroscience1878-92932025-01-0171101491The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantageET. Marcelle0H. Yang1JW. Cohen2B. Ramphal3D. Pagliaccio4V. Rauh5BS. Peterson6F. Perera7H. Andrews8AG. Rundle9J. Herbstman10AE. Margolis11Department of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USADivision of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USAChild Mind Institute, New York, NY, USAHarvard TH Chan School of Public Health, Boston, MA, USA; Harvard Medical School, Boston, MA, USADepartment of Psychiatry, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Division of Child and Adolescent Psychiatry, New York State Psychiatric Institute, New York, NY, USAHeilbrunn Department of Population and Family Health, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Psychiatry at the Keck School of Medicine, University of Southern California, and Children's Hospital of Los Angeles, Los Angeles, CA, USAColumbia Center for Children’s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USADepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USAColumbia Center for Children’s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USAChild Mind Institute, New York, NY, USA; Department of Psychiatry and Behavioral Health, The Ohio State University, Columbus, OH, USA; Correspondence to: Prior Hall, Suite 260 376 W 10th Avenue, Columbus, OH 43210.A left-lateralized cortical reading circuit underlies successful reading and fails to engage in individuals with reading problems. Studies identifying this circuit included youth from economically advantaged backgrounds and focused on cortical, not subcortical, structures. However, among youth with low scores on reading tests who are living in the context of economic disadvantage, this brain network is actively engaged during reading, despite persistent reading problems. This finding suggests that other brain circuits may underlie reading in these youth. A hippocampal circuit is one likely candidate, as it has recently been shown to support domain-general processes like working memory (WM) that are also associated with reading. Given age-related increases in hippocampal volume, WM, and reading, and known associations between WM and reading, we hypothesized that hippocampal volume would be associated with reading via WM processes. Using a cross-sectional developmental design, we explored this in middle childhood (average age at MRI scan ∼10; N = 50) and adolescence (average age at MRI scan ∼17; N = 175). Results suggest that the hippocampus is a critical contributor to word reading in adolescents living in economically disadvantaged contexts, and that this operates through working memory processes. Such findings point to new targets for reading intervention in adolescents.http://www.sciencedirect.com/science/article/pii/S187892932400152XWorking memoryBrain developmentEconomic disadvantageHippocampusWord reading |
| spellingShingle | ET. Marcelle H. Yang JW. Cohen B. Ramphal D. Pagliaccio V. Rauh BS. Peterson F. Perera H. Andrews AG. Rundle J. Herbstman AE. Margolis The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage Developmental Cognitive Neuroscience Working memory Brain development Economic disadvantage Hippocampus Word reading |
| title | The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage |
| title_full | The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage |
| title_fullStr | The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage |
| title_full_unstemmed | The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage |
| title_short | The role of the hippocampus in working memory and word reading: Novel neural correlates of reading among youth living in the context of economic disadvantage |
| title_sort | role of the hippocampus in working memory and word reading novel neural correlates of reading among youth living in the context of economic disadvantage |
| topic | Working memory Brain development Economic disadvantage Hippocampus Word reading |
| url | http://www.sciencedirect.com/science/article/pii/S187892932400152X |
| work_keys_str_mv | AT etmarcelle theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT hyang theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT jwcohen theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT bramphal theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT dpagliaccio theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT vrauh theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT bspeterson theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT fperera theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT handrews theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT agrundle theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT jherbstman theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT aemargolis theroleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT etmarcelle roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT hyang roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT jwcohen roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT bramphal roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT dpagliaccio roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT vrauh roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT bspeterson roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT fperera roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT handrews roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT agrundle roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT jherbstman roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage AT aemargolis roleofthehippocampusinworkingmemoryandwordreadingnovelneuralcorrelatesofreadingamongyouthlivinginthecontextofeconomicdisadvantage |