The characteristics of peripheral blood lymphocyte main subsets in rheumatoid arthritis patients concurrent with hepatitis b virus infection: a retrospective cohort study
Abstract Objective The distribution of peripheral blood lymphocytes may change due to the influence of diseases. This study aims to investigate the impact of Hepatitis B virus (HBV) infection on the distribution of peripheral blood lymphocyte subsets in patients with Rheumatoid Arthritis (RA). Metho...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-04-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-025-10932-4 |
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| Summary: | Abstract Objective The distribution of peripheral blood lymphocytes may change due to the influence of diseases. This study aims to investigate the impact of Hepatitis B virus (HBV) infection on the distribution of peripheral blood lymphocyte subsets in patients with Rheumatoid Arthritis (RA). Methods Two hundred ninety-eight patients were recruited from a retrospective cohort of patients with RA. Patients with RA (n = 43) who had hepatitis B surface antigen (HBsAg) positivity in the serum were categorized into the HBV group (HBV-RA group), while 255 RA patients without HBsAg positivity were assigned to the control group. The patients in the HBV-RA group were further divided into two subgroups based on their levels of HBV DNA: those with levels below the lower limit of quantification (< 20 IU/ml) formed the HBV DNAlow group, while those with levels above or equal to this limit (≥ 20 IU/ml) constituted the HBV DNAhigh group. Demographic, clinical and laboratory data were also collected. Results Compared with those of the control group, a higher proportion of CD19+ B cells and CD8+ T cells and a lower CD4+/CD8+ ratio were observed in the HBV-RA group (all P < 0.05). The same trend was observed in the HBV DNAhigh group compared to the HBV DNAlow group (all P < 0.05). Additionally, based on multivariable logistic regression analysis, the male gender, DAS-28 ≥ 2.6, a high proportion of CD19 + B and CD8 + T cells, and the elevated levels of rheumatoid factor (RF) were found to be significantly associated with RA concurrent with HBV infection (all P < 0.05). In the HBV-RA group, a correlation analysis was conducted revealing a positive association between CD19 + B cells and DAS-28 score, as well as CD8 + T cells and DAS-28 score. There was no statistically significant difference in CD4/CD8 ratio between different DAS-28 groups, however the study revealed a significant negative association between the ratio of CD4 +/CD8 + and the DAS-28 score. Conclusion The high proportion of CD19 + B and CD8 + T cells were closely associated with RA concurrent with HBV infection. |
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| ISSN: | 1471-2334 |