Animal models of rheumatoid arthritis‐associated interstitial lung disease
Abstract Background Rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is an irreversible pathologic condition of unknown cause, commonly involving the joint and the lung with variable amounts of fibrotic change. In contrast to rheumatoid arthritis or other chronic interstitial lung...
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.377 |
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| author | Li Xiong Liang Xiong Hong Ye Wan‐Li Ma |
| author_facet | Li Xiong Liang Xiong Hong Ye Wan‐Li Ma |
| author_sort | Li Xiong |
| collection | DOAJ |
| description | Abstract Background Rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is an irreversible pathologic condition of unknown cause, commonly involving the joint and the lung with variable amounts of fibrotic change. In contrast to rheumatoid arthritis or other chronic interstitial lung diseases such as interstitial pulmonary fibrosis, there is so far no extensively accepted or implemented animal model for this disease. Aims To provide guidance for those who are investigating the pathogenesis of RA‐ILD with animal models. Materials and Methods An analysis of papers from PubMed during 1978‐2020. Results We outline the present status quo for animal models of RA‐ILD about their modeling methods and pathogenesis, compare their pros and cons with respect to their ability to mimic the clinical and histological features of human disease and discuss their applicability for future research. Discussion There is no doubt that these animal models do provide valuable information relating to the pathogenesis of RA‐ILD and the development of effective therapeutic drugs. Nevertheless, these animal models can not entirely recapitulate clinical pathology and have some limitations in experimental research application. Therefore, it should be emphasized that we should improve and explore animal models in more accordance with the pathogenesis and clinical characteristics of human RA‐ILD. Conclusion These established animal models of the disease can significantly progress our understanding of the etiology of RA‐ILD, the fundamental mechanisms of its pathogenesis and the identification of new bio‐markers, and can contribute to the development and implementation of novel treatment strategies. |
| format | Article |
| id | doaj-art-7949edaf6a9a4fe9bc2d42ae49b802a9 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-7949edaf6a9a4fe9bc2d42ae49b802a92025-08-20T02:15:41ZengWileyImmunity, Inflammation and Disease2050-45272021-03-0191374710.1002/iid3.377Animal models of rheumatoid arthritis‐associated interstitial lung diseaseLi Xiong0Liang Xiong1Hong Ye2Wan‐Li Ma3Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Pathophysiology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaDepartment of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan ChinaAbstract Background Rheumatoid arthritis‐associated interstitial lung disease (RA‐ILD) is an irreversible pathologic condition of unknown cause, commonly involving the joint and the lung with variable amounts of fibrotic change. In contrast to rheumatoid arthritis or other chronic interstitial lung diseases such as interstitial pulmonary fibrosis, there is so far no extensively accepted or implemented animal model for this disease. Aims To provide guidance for those who are investigating the pathogenesis of RA‐ILD with animal models. Materials and Methods An analysis of papers from PubMed during 1978‐2020. Results We outline the present status quo for animal models of RA‐ILD about their modeling methods and pathogenesis, compare their pros and cons with respect to their ability to mimic the clinical and histological features of human disease and discuss their applicability for future research. Discussion There is no doubt that these animal models do provide valuable information relating to the pathogenesis of RA‐ILD and the development of effective therapeutic drugs. Nevertheless, these animal models can not entirely recapitulate clinical pathology and have some limitations in experimental research application. Therefore, it should be emphasized that we should improve and explore animal models in more accordance with the pathogenesis and clinical characteristics of human RA‐ILD. Conclusion These established animal models of the disease can significantly progress our understanding of the etiology of RA‐ILD, the fundamental mechanisms of its pathogenesis and the identification of new bio‐markers, and can contribute to the development and implementation of novel treatment strategies.https://doi.org/10.1002/iid3.377animal modelsautoimmune diseaseinterstitial lung diseaselung inflammationrheumatoid arthritis |
| spellingShingle | Li Xiong Liang Xiong Hong Ye Wan‐Li Ma Animal models of rheumatoid arthritis‐associated interstitial lung disease Immunity, Inflammation and Disease animal models autoimmune disease interstitial lung disease lung inflammation rheumatoid arthritis |
| title | Animal models of rheumatoid arthritis‐associated interstitial lung disease |
| title_full | Animal models of rheumatoid arthritis‐associated interstitial lung disease |
| title_fullStr | Animal models of rheumatoid arthritis‐associated interstitial lung disease |
| title_full_unstemmed | Animal models of rheumatoid arthritis‐associated interstitial lung disease |
| title_short | Animal models of rheumatoid arthritis‐associated interstitial lung disease |
| title_sort | animal models of rheumatoid arthritis associated interstitial lung disease |
| topic | animal models autoimmune disease interstitial lung disease lung inflammation rheumatoid arthritis |
| url | https://doi.org/10.1002/iid3.377 |
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