Ministring DNA (msDNA): a novel linear covalently-closed DNA with enhanced stability for gene and cell therapy applications

Ministring DNA (msDNA): a novel linear covalently-closed DNA with enhanced stability for gene and cell therapy applications

Abstract The quality and fidelity of DNA vectors used in genetic medicine and gene therapy either as starting material for manufacturing or as therapeutic ingredients play a critical role in determining ultimate clinical success. Ministring DNA (msDNA), is a novel minivector that is a linear covalen...

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Bibliographic Details
Main Authors: Wai Kuen Hung, Siddarth Chandrasekaran, Olga Zaslaver, Ming Zhu, Jamie Lam, Steven Hersch, Peyman Mokarami, Roderick A. Slavcev, Nafiseh Nafissi
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
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Keywords
Ministring DNA
Linear covalently closed DNA
Gene therapy
Chemical and mechanical stability
Lyophilization
Online Access:https://doi.org/10.1038/s41598-025-98730-5
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