Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma
Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction. Methods: A single-center observational cross-sectional pilot study was conducted. Eig...
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Open Exploration Publishing Inc.
2025-06-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1001338/1001338.pdf |
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| author | Regina N. Khramova Elena V. Tush Tatyana I. Eliseeva Dmitriy Yu. Ovsyannikov Svetlana V. Krasilnikova Maxim A. Karpenko Natalia A. Geppe Nailya I. Kubysheva Olga V. Khaletskaya |
| author_facet | Regina N. Khramova Elena V. Tush Tatyana I. Eliseeva Dmitriy Yu. Ovsyannikov Svetlana V. Krasilnikova Maxim A. Karpenko Natalia A. Geppe Nailya I. Kubysheva Olga V. Khaletskaya |
| author_sort | Regina N. Khramova |
| collection | DOAJ |
| description | Aim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction. Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese. Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18. Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese. |
| format | Article |
| id | doaj-art-794712752c48432fb2a005d5b55595ae |
| institution | Kabale University |
| issn | 2692-3106 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Open Exploration Publishing Inc. |
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| series | Exploration of Medicine |
| spelling | doaj-art-794712752c48432fb2a005d5b55595ae2025-08-20T03:24:11ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-06-016100133810.37349/emed.2025.1001338Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthmaRegina N. Khramova0https://orcid.org/0000-0002-2396-5054Elena V. Tush1https://orcid.org/0000-0002-5961-9794Tatyana I. Eliseeva2https://orcid.org/0000-0002-1769-3670Dmitriy Yu. Ovsyannikov3https://orcid.org/0000-0002-4961-384XSvetlana V. Krasilnikova4https://orcid.org/0000-0001-6153-6691Maxim A. Karpenko5https://orcid.org/0000-0001-7937-722XNatalia A. Geppe6https://orcid.org/0000-0003-0547-3686Nailya I. Kubysheva7https://orcid.org/0000-0002-5582-5814Olga V. Khaletskaya8https://orcid.org/0000-0002-8531-3174Pediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian Federation; Institute of Clinical Medicine, National Research Lobachevsky State University of Nizhny Novgorod, 603022 Nizhny Novgorod, Russian FederationPediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian FederationPediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian FederationMedical Institute, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian FederationPediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian FederationMedical Institute, Peoples’ Friendship University of Russia (RUDN University), 117198 Moscow, Russian FederationClinical Institute of Children’s Health named after N.F. Filatov, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russian FederationNeurocognitive Research Laboratory, Kazan Federal University, 420000 Kazan, Russian FederationPediatric Department, Privolzhsky Research Medical University, 603950 Nizhny Novgorod, Russian FederationAim: To study the effect of body mass index (BMI) on interleukin (IL)-6 and IL-18 levels in children and adolescents with bronchial asthma (BA), taking into account the presence or absence of bronchial obstruction. Methods: A single-center observational cross-sectional pilot study was conducted. Eighty-six patients with BA aged from 8 to 17 years were studied. Anthropometric and spirometric parameters and IL-6, IL-18 levels were assessed. The study participants were divided into 2 groups: 1—patients with normal body weight (BW), 2—overweight/obese. Results: The serum levels of IL-6 and IL-18 were statistically significantly higher in overweight/obese patients than in normal BW patients, being 1.18 [0.10; 3.27] pg/mL vs. 0.52 [0.10; 1.34] pg/mL, P = 0.036 and 251.0 [207.0; 346.0] pg/mL vs. 208.0 [134.0; 293.0] pg/mL, P = 0.012, respectively. Statistically significant direct correlations of IL-6 and IL-18 with z BMI were obtained in the total group: R = 0.35, P = 0.001; R = 0.37, P = 0.002, respectively. In the overweight/obese group, IL-6 and IL-18 levels were statistically significantly higher in patients with obstruction [z forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) < –1.645 z] than in patients without obstruction (z FEV1/FVC > –1.645 z), respectively: 1.74 [1.10; 5.41] pg/mL vs. 0.59 [0.50; 1.48] pg/mL, P = 0.026 for IL-6 and 298.50 [207.00; 425.00] pg/mL vs. 234.50 [207.00; 300.00] pg/mL, P = 0.046 for IL-18. Conclusions: In patients with BA and overweight/obese, but not in patients with BA and normal BW, the presence of bronchial obstruction is associated with higher serum levels of IL-6, IL-18. This may indicate the involvement of these ILs in the genesis of bronchial obstruction in patients with BA and overweight/obese.https://www.explorationpub.com/uploads/Article/A1001338/1001338.pdfasthmachildrenoverweightobesityil-6il-18 |
| spellingShingle | Regina N. Khramova Elena V. Tush Tatyana I. Eliseeva Dmitriy Yu. Ovsyannikov Svetlana V. Krasilnikova Maxim A. Karpenko Natalia A. Geppe Nailya I. Kubysheva Olga V. Khaletskaya Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma Exploration of Medicine asthma children overweight obesity il-6 il-18 |
| title | Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma |
| title_full | Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma |
| title_fullStr | Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma |
| title_full_unstemmed | Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma |
| title_short | Impact of BMI on IL-6 and IL-18 levels in children and adolescents with asthma |
| title_sort | impact of bmi on il 6 and il 18 levels in children and adolescents with asthma |
| topic | asthma children overweight obesity il-6 il-18 |
| url | https://www.explorationpub.com/uploads/Article/A1001338/1001338.pdf |
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