Unveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy

Unveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy

BackgroundIn the absence of a human leukocyte antigen (HLA)-matched donor, intensive immunosuppressive therapy (IST) combined with unrelated cord blood (IIST-UCB) a salvage treatment option for patients with severe aplastic anemia (SAA) who had failed IST. With advancements in transplantation techno...

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Bibliographic Details
Main Authors: Zhipeng Li, Xiaolin Yu, Xiaochen Song, Wenjun Li, Lei Deng, Fanjun Kong, Jing Wang, Meiling Ni, Fang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
unrelated cord blood
severe aplastic anemia
immunosuppressive therapy
SAA
chimerism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1622326/full
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