No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients
Despite significant efforts, there is still an existing need to identify diagnostic tools that would enable fast and reliable detection of the progressive stage of multiple sclerosis (MS) and help in monitoring the disease course and/or treatment effects. The aim of this prospective study in a group...
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2025-01-01
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| author | Bartosz Gajewski Iwona Karlińska Małgorzata Domowicz Igor Bednarski Mariola Świderek-Matysiak Mariusz Stasiołek |
| author_facet | Bartosz Gajewski Iwona Karlińska Małgorzata Domowicz Igor Bednarski Mariola Świderek-Matysiak Mariusz Stasiołek |
| author_sort | Bartosz Gajewski |
| collection | DOAJ |
| description | Despite significant efforts, there is still an existing need to identify diagnostic tools that would enable fast and reliable detection of the progressive stage of multiple sclerosis (MS) and help in monitoring the disease course and/or treatment effects. The aim of this prospective study in a group of people with progressive MS was to determine whether changes in the levels of selected serum biomarkers and in cognitive function may predict disease progression, and therefore refine the decision-making process in the evaluation of MS patients. Forty two (42) patients with progressive MS completed all the study procedures; the mean duration of follow-up was 12.97 months. During the observation period, serum concentration of chitinase-3 like-protein-1 (CHI3L1/YKL-40) decreased significantly in the whole study group (from 4034.95 ± 262.62 to 2866.43 ± 173.37; <i>p</i> = 0.0005), as well as in subgroups of people with secondary progressive and primary progressive MS (SPMS: from 3693.81 ± 388.68 to 2542.76 ± 256.59; <i>p</i> = 0.0207; and PPMS: from 4376.09 ± 353.27 to 3190.09 ± 233.22; <i>p</i> = 0.0089, respectively). A significant worsening of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) scores was detected in the whole study group (from 1.18 ± 0.14 to 1.34 ± 0.15; <i>p</i> = 0.0331) as well as in the PPMS subgroup (from 1.04 ± 0.18 to 1.26 ± 0.20; <i>p</i> = 0.0216). No correlations between the analyzed molecular parameters or the results of neuropsychological tests and physical disability were observed. In conclusion, an emphasis should be placed on furthering the search for multimodal biomarkers of disease progression, especially in the PMS population, based on simultaneous analysis of several factors, such as blood biomarkers and cognitive profiles. |
| format | Article |
| id | doaj-art-794535e79b2041c9ba93af49870c29a5 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-794535e79b2041c9ba93af49870c29a52025-01-24T13:25:03ZengMDPI AGBiomolecules2218-273X2025-01-011516810.3390/biom15010068No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis PatientsBartosz Gajewski0Iwona Karlińska1Małgorzata Domowicz2Igor Bednarski3Mariola Świderek-Matysiak4Mariusz Stasiołek5Department of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDepartment of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, PolandDespite significant efforts, there is still an existing need to identify diagnostic tools that would enable fast and reliable detection of the progressive stage of multiple sclerosis (MS) and help in monitoring the disease course and/or treatment effects. The aim of this prospective study in a group of people with progressive MS was to determine whether changes in the levels of selected serum biomarkers and in cognitive function may predict disease progression, and therefore refine the decision-making process in the evaluation of MS patients. Forty two (42) patients with progressive MS completed all the study procedures; the mean duration of follow-up was 12.97 months. During the observation period, serum concentration of chitinase-3 like-protein-1 (CHI3L1/YKL-40) decreased significantly in the whole study group (from 4034.95 ± 262.62 to 2866.43 ± 173.37; <i>p</i> = 0.0005), as well as in subgroups of people with secondary progressive and primary progressive MS (SPMS: from 3693.81 ± 388.68 to 2542.76 ± 256.59; <i>p</i> = 0.0207; and PPMS: from 4376.09 ± 353.27 to 3190.09 ± 233.22; <i>p</i> = 0.0089, respectively). A significant worsening of Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) scores was detected in the whole study group (from 1.18 ± 0.14 to 1.34 ± 0.15; <i>p</i> = 0.0331) as well as in the PPMS subgroup (from 1.04 ± 0.18 to 1.26 ± 0.20; <i>p</i> = 0.0216). No correlations between the analyzed molecular parameters or the results of neuropsychological tests and physical disability were observed. In conclusion, an emphasis should be placed on furthering the search for multimodal biomarkers of disease progression, especially in the PMS population, based on simultaneous analysis of several factors, such as blood biomarkers and cognitive profiles.https://www.mdpi.com/2218-273X/15/1/68progressive multiple sclerosisbiomarkerscognitive impairmentprogressionneurofilament light chainchitanse-3 like-protein-1 |
| spellingShingle | Bartosz Gajewski Iwona Karlińska Małgorzata Domowicz Igor Bednarski Mariola Świderek-Matysiak Mariusz Stasiołek No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients Biomolecules progressive multiple sclerosis biomarkers cognitive impairment progression neurofilament light chain chitanse-3 like-protein-1 |
| title | No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients |
| title_full | No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients |
| title_fullStr | No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients |
| title_full_unstemmed | No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients |
| title_short | No Relation Between Cognitive Impairment, Physical Disability and Serum Biomarkers in a Cohort of Progressive Multiple Sclerosis Patients |
| title_sort | no relation between cognitive impairment physical disability and serum biomarkers in a cohort of progressive multiple sclerosis patients |
| topic | progressive multiple sclerosis biomarkers cognitive impairment progression neurofilament light chain chitanse-3 like-protein-1 |
| url | https://www.mdpi.com/2218-273X/15/1/68 |
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