Metal‐Coordinated NIR‐II Nanoadjuvants with Nanobody Conjugation for Potentiating Immunotherapy by Tumor Metabolism Reprogramming

Metal‐Coordinated NIR‐II Nanoadjuvants with Nanobody Conjugation for Potentiating Immunotherapy by Tumor Metabolism Reprogramming

Abstract Immune checkpoint blockade (ICB) immunotherapy remains hampered by insufficient immunogenicity and a high‐lactate immunosuppressive tumor microenvironment (TME). Herein, a nanobody‐engineered NIR‐II nanoadjuvant with targeting metabolic reprogramming capability is constructed for potentiati...

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Bibliographic Details
Main Authors: Yeneng Dai, Ziang Guo, Dongliang Leng, Guanda Jiao, Kai Chen, Mingxuan Fu, Yang Liu, Qingming Shen, Qi Wang, Lipeng Zhu, Qi Zhao
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Advanced Science
Subjects:
amplified immunotherapy
lactate efflux
nanoadjuvants
nanobody
NIR‐II phototheranostics
Online Access:https://doi.org/10.1002/advs.202404886
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