Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study
An important aspect of functional magnetic resonance imaging (fMRI) is the study of brain hemodynamics, and MR arterial spin labeling (ASL) perfusion imaging has gained wide acceptance as a robust and noninvasive technique. However, the cerebral blood flow (CBF) measurements obtained with ASL fMRI h...
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Wiley
2008-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2008/516359 |
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| author | Jean J. Chen Marguerite Wieckowska Ernst Meyer G. Bruce Pike |
| author_facet | Jean J. Chen Marguerite Wieckowska Ernst Meyer G. Bruce Pike |
| author_sort | Jean J. Chen |
| collection | DOAJ |
| description | An important aspect of functional magnetic resonance imaging (fMRI) is the study of brain hemodynamics, and MR arterial spin labeling (ASL) perfusion imaging has gained wide acceptance as a robust and noninvasive technique. However, the cerebral blood flow (CBF) measurements obtained with ASL fMRI have not been fully validated, particularly during global CBF modulations. We present a comparison of cerebral blood flow changes (ΔCBF) measured using a flow-sensitive alternating inversion recovery (FAIR) ASL perfusion method to those obtained using H2O15 PET, which is the current gold standard for in vivo imaging of CBF. To study regional and global CBF changes, a group of 10 healthy volunteers were imaged under identical experimental conditions during presentation of 5 levels of visual stimulation and one level of hypercapnia. The CBF changes were compared using 3 types of region-of-interest (ROI) masks. FAIR measurements of CBF changes were found to be slightly lower than those measured with PET (average ΔCBF of 21.5±8.2% for FAIR versus 28.2±12.8% for PET at maximum stimulation intensity). Nonetheless, there was a strong correlation between measurements of the two modalities. Finally, a t-test comparison of the slopes of the linear fits of PET versus ASL ΔCBF for all 3 ROI types indicated no significant difference from unity (P>.05). |
| format | Article |
| id | doaj-art-793fdc4723a847ec98c25ce792f72a2d |
| institution | OA Journals |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2008-01-01 |
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| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-793fdc4723a847ec98c25ce792f72a2d2025-08-20T02:07:31ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962008-01-01200810.1155/2008/516359516359Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation StudyJean J. Chen0Marguerite Wieckowska1Ernst Meyer2G. Bruce Pike3McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, PQ, H3A 2B4, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, PQ, H3A 2B4, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, PQ, H3A 2B4, CanadaMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, PQ, H3A 2B4, CanadaAn important aspect of functional magnetic resonance imaging (fMRI) is the study of brain hemodynamics, and MR arterial spin labeling (ASL) perfusion imaging has gained wide acceptance as a robust and noninvasive technique. However, the cerebral blood flow (CBF) measurements obtained with ASL fMRI have not been fully validated, particularly during global CBF modulations. We present a comparison of cerebral blood flow changes (ΔCBF) measured using a flow-sensitive alternating inversion recovery (FAIR) ASL perfusion method to those obtained using H2O15 PET, which is the current gold standard for in vivo imaging of CBF. To study regional and global CBF changes, a group of 10 healthy volunteers were imaged under identical experimental conditions during presentation of 5 levels of visual stimulation and one level of hypercapnia. The CBF changes were compared using 3 types of region-of-interest (ROI) masks. FAIR measurements of CBF changes were found to be slightly lower than those measured with PET (average ΔCBF of 21.5±8.2% for FAIR versus 28.2±12.8% for PET at maximum stimulation intensity). Nonetheless, there was a strong correlation between measurements of the two modalities. Finally, a t-test comparison of the slopes of the linear fits of PET versus ASL ΔCBF for all 3 ROI types indicated no significant difference from unity (P>.05).http://dx.doi.org/10.1155/2008/516359 |
| spellingShingle | Jean J. Chen Marguerite Wieckowska Ernst Meyer G. Bruce Pike Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study International Journal of Biomedical Imaging |
| title | Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study |
| title_full | Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study |
| title_fullStr | Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study |
| title_full_unstemmed | Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study |
| title_short | Cerebral Blood Flow Measurement Using fMRI and PET: A Cross-Validation Study |
| title_sort | cerebral blood flow measurement using fmri and pet a cross validation study |
| url | http://dx.doi.org/10.1155/2008/516359 |
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