Fall in Vitamin D Levels during Hospitalization in Children
Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mea...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2014/291856 |
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| author | Devi Dayal Suresh Kumar Naresh Sachdeva Rakesh Kumar Meenu Singh Sunit Singhi |
| author_facet | Devi Dayal Suresh Kumar Naresh Sachdeva Rakesh Kumar Meenu Singh Sunit Singhi |
| author_sort | Devi Dayal |
| collection | DOAJ |
| description | Plasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P=0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters. |
| format | Article |
| id | doaj-art-793916b16855443a8088c9103fdb7205 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-793916b16855443a8088c9103fdb72052025-02-03T01:23:31ZengWileyInternational Journal of Pediatrics1687-97401687-97592014-01-01201410.1155/2014/291856291856Fall in Vitamin D Levels during Hospitalization in ChildrenDevi Dayal0Suresh Kumar1Naresh Sachdeva2Rakesh Kumar3Meenu Singh4Sunit Singhi5Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaDepartment of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, IndiaPlasma levels of 25-hydroxyvitamin D [25(OH)D] were measured by competitive Electrochemiluminescence Immunoassay (ECLIA) in 92 children (67 boys, 25 girls) aged 3 months to 12 years at admission to hospital (timepoint 1, T1) and at discharge (timepoint 2, T2). There was a significant fall in the mean 25(OH)D from T1 (71.87 ± 27.25 nmol/L) to T2 (49.03 ± 22.25 nmol/L) (mean change = 22.84 nmol/L, P value = 0.0004). Proportion of patients having VDD (levels <50 nmol/L) at admission (25%, 23/92) increased significantly at the time of discharge (51.09%, 47/92) (P=0.0004). There was a trend towards longer duration of hospital stay, requirement of ventilation and inotropes, development of healthcare-associated infection, and mortality in vitamin D deficient as compared to nondeficient patients though the difference was statistically insignificant. In conclusion, vitamin D levels fall significantly and should be monitored during hospital stay in children. Large clinical studies are needed to prospectively evaluate the effect of vitamin D supplementation in vitamin D deficient hospitalized children on various disease outcome parameters.http://dx.doi.org/10.1155/2014/291856 |
| spellingShingle | Devi Dayal Suresh Kumar Naresh Sachdeva Rakesh Kumar Meenu Singh Sunit Singhi Fall in Vitamin D Levels during Hospitalization in Children International Journal of Pediatrics |
| title | Fall in Vitamin D Levels during Hospitalization in Children |
| title_full | Fall in Vitamin D Levels during Hospitalization in Children |
| title_fullStr | Fall in Vitamin D Levels during Hospitalization in Children |
| title_full_unstemmed | Fall in Vitamin D Levels during Hospitalization in Children |
| title_short | Fall in Vitamin D Levels during Hospitalization in Children |
| title_sort | fall in vitamin d levels during hospitalization in children |
| url | http://dx.doi.org/10.1155/2014/291856 |
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