Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease
The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson’s disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 3...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/1648017 |
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| author | Yanna Ren Keisuke Suzuki Weiping Yang Yanling Ren Fengxia Wu Jiajia Yang Satoshi Takahashi Yoshimichi Ejima Jinglong Wu Koichi Hirata |
| author_facet | Yanna Ren Keisuke Suzuki Weiping Yang Yanling Ren Fengxia Wu Jiajia Yang Satoshi Takahashi Yoshimichi Ejima Jinglong Wu Koichi Hirata |
| author_sort | Yanna Ren |
| collection | DOAJ |
| description | The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson’s disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p<0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p<0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p>0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD. |
| format | Article |
| id | doaj-art-793776a2f6ff415dbe4fc33403889541 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-793776a2f6ff415dbe4fc334038895412025-08-20T03:35:23ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/16480171648017Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s DiseaseYanna Ren0Keisuke Suzuki1Weiping Yang2Yanling Ren3Fengxia Wu4Jiajia Yang5Satoshi Takahashi6Yoshimichi Ejima7Jinglong Wu8Koichi Hirata9Department of Psychology, Medical Humanities College, Guiyang University of Chinese Medicine, Guiyang 550025, ChinaDepartment of Neurology, Dokkyo Medical University, Tochigi 3210293, JapanDepartment of Psychology, Hubei University, Wuhan 430062, ChinaDepartment of Light and Chemical Engineering, Guizhou Light Industry Technical College, Guiyang 550025, ChinaCognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, JapanCognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, JapanCognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, JapanCognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, JapanCognitive Neuroscience Laboratory, Graduate School of Natural Science and Technology, Okayama University, Okayama 7008530, JapanDepartment of Neurology, Dokkyo Medical University, Tochigi 3210293, JapanThe basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson’s disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p<0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p<0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p>0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD.http://dx.doi.org/10.1155/2018/1648017 |
| spellingShingle | Yanna Ren Keisuke Suzuki Weiping Yang Yanling Ren Fengxia Wu Jiajia Yang Satoshi Takahashi Yoshimichi Ejima Jinglong Wu Koichi Hirata Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease Parkinson's Disease |
| title | Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease |
| title_full | Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease |
| title_fullStr | Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease |
| title_full_unstemmed | Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease |
| title_short | Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson’s Disease |
| title_sort | absent audiovisual integration elicited by peripheral stimuli in parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/1648017 |
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