Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems
Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders....
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/8576890 |
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| _version_ | 1849409829219598336 |
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| author | Suliman Khan Pengfei Duan Lunguang Yao Hongwei Hou |
| author_facet | Suliman Khan Pengfei Duan Lunguang Yao Hongwei Hou |
| author_sort | Suliman Khan |
| collection | DOAJ |
| description | Shiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork. |
| format | Article |
| id | doaj-art-7933a85ea29d4c49ae01b8dce3bddcd7 |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-7933a85ea29d4c49ae01b8dce3bddcd72025-08-20T03:35:23ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/85768908576890Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health ProblemsSuliman Khan0Pengfei Duan1Lunguang Yao2Hongwei Hou3The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, ChinaCollaborative Innovation Center of Water and Security for Water Source Region of Mid-Line of South-to-North Diversion Project, College of Agricultural Engineering, Nanyang Normal University, Nanyang, Henan, ChinaCollaborative Innovation Center of Water and Security for Water Source Region of Mid-Line of South-to-North Diversion Project, College of Agricultural Engineering, Nanyang Normal University, Nanyang, Henan, ChinaThe Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, ChinaShiftwork became common during the last few decades with the growing demands of human life. Despite the social inactivity and irregularity in habits, working in continuous irregular shifts causes serious health issues including sleep disorders, psychiatric disorders, cancer, and metabolic disorders. These health problems arise due to the disruption in circadian clock system, which is associated with alterations in genetic expressions. Alteration in clock controlling genes further affects genes linked with disorders including major depression disorder, bipolar disorder, phase delay and phase advance sleep syndromes, breast cancer, and colon cancer. A diverse research work is needed focusing on broad spectrum changes caused by jet lag in brain and neuronal system. This review is an attempt to motivate the researchers to conduct advanced studies in this area to identify the risk factors and mechanisms. Its goal is extended to make the shift workers aware about the risks associated with shiftwork.http://dx.doi.org/10.1155/2018/8576890 |
| spellingShingle | Suliman Khan Pengfei Duan Lunguang Yao Hongwei Hou Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems International Journal of Genomics |
| title | Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems |
| title_full | Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems |
| title_fullStr | Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems |
| title_full_unstemmed | Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems |
| title_short | Shiftwork-Mediated Disruptions of Circadian Rhythms and Sleep Homeostasis Cause Serious Health Problems |
| title_sort | shiftwork mediated disruptions of circadian rhythms and sleep homeostasis cause serious health problems |
| url | http://dx.doi.org/10.1155/2018/8576890 |
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