The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats
The prevalence of diabetes mellitus (Type II) has reached alarming levels globally and the natural product constituents showed significant features that are considered potential alternative agents in this field. The current work focuses on studying certain hypoglycemic natural extracts with antidiab...
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Elsevier
2025-06-01
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| Series: | Journal of Agriculture and Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154325002625 |
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| author | Eman R. Elsharkawy Ali Alqahtani Md Nazim Uddin Forhad Khan Yong He Xiaoli Li Mostafa M. Gouda |
| author_facet | Eman R. Elsharkawy Ali Alqahtani Md Nazim Uddin Forhad Khan Yong He Xiaoli Li Mostafa M. Gouda |
| author_sort | Eman R. Elsharkawy |
| collection | DOAJ |
| description | The prevalence of diabetes mellitus (Type II) has reached alarming levels globally and the natural product constituents showed significant features that are considered potential alternative agents in this field. The current work focuses on studying certain hypoglycemic natural extracts with antidiabetic implications. In the methods, the antidiabetic, hematological, and antioxidant study of methanol extract of Schimpera arabica in streptozotocin-induced diabetic rats was conducted in vivo. The rats were induced for diabetes with streptozotocin (STZ) at a dosage of 58 mg/kg. Then 5 groups were separately administrated with the extract (400 mg/kg), metformin (100 mg/kg), and insulin (10 U/kg) according to the experimental design. The results show that 400 mg/kg of S. arabica extract for 2 weeks significantly reduced blood glucose (279.5 ± 24.6 mg/dl) compared to the STZ group with 550.5 ± 15.39 mg/dl. It also exhibited an increased number of white blood cells (WBCs) and red blood cells (RBCs) compared to metformin and insulin. The extract showed a significant decrease in hemoglobin concentration by about 6.3 %, and the platelet count showed a comparable decrease of 7.2 % compared to the diabetic group. The treatment with extract for 15 days showed a favorable effect on the histopathological change of the pancreas in diabetic rat groups. Phenolic compounds, as identified by LC-MS/MS, have interacted with 115 unique target proteins. In conclusion, the current results suggest the usefulness of the plant extract as an effective adjuvant antidiabetic agent. |
| format | Article |
| id | doaj-art-792bdd1db5544a58b7a202e3cbcb1074 |
| institution | DOAJ |
| issn | 2666-1543 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj-art-792bdd1db5544a58b7a202e3cbcb10742025-08-20T03:10:25ZengElsevierJournal of Agriculture and Food Research2666-15432025-06-012110189110.1016/j.jafr.2025.101891The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic ratsEman R. Elsharkawy0Ali Alqahtani1Md Nazim Uddin2Forhad Khan3Yong He4Xiaoli Li5Mostafa M. Gouda6Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia; Department of Chemistry, College of Science, Northern Border University, Arar, 73213, Saudi Arabia; Corresponding author. Center for Health Research, Northern Border University, Arar, 73213, Saudi Arabia.Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, 62529, Kingdom of Saudi ArabiaInstitute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, 1205, BangladeshDepartment of Chemistry, University of Massachusetts Boston, Boston, MA, 02125, United StatesCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, ChinaCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; Corresponding author.College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China; Department of Nutrition & Food Science, National Research Centre, Giza, 12622, Egypt; Corresponding author. College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.The prevalence of diabetes mellitus (Type II) has reached alarming levels globally and the natural product constituents showed significant features that are considered potential alternative agents in this field. The current work focuses on studying certain hypoglycemic natural extracts with antidiabetic implications. In the methods, the antidiabetic, hematological, and antioxidant study of methanol extract of Schimpera arabica in streptozotocin-induced diabetic rats was conducted in vivo. The rats were induced for diabetes with streptozotocin (STZ) at a dosage of 58 mg/kg. Then 5 groups were separately administrated with the extract (400 mg/kg), metformin (100 mg/kg), and insulin (10 U/kg) according to the experimental design. The results show that 400 mg/kg of S. arabica extract for 2 weeks significantly reduced blood glucose (279.5 ± 24.6 mg/dl) compared to the STZ group with 550.5 ± 15.39 mg/dl. It also exhibited an increased number of white blood cells (WBCs) and red blood cells (RBCs) compared to metformin and insulin. The extract showed a significant decrease in hemoglobin concentration by about 6.3 %, and the platelet count showed a comparable decrease of 7.2 % compared to the diabetic group. The treatment with extract for 15 days showed a favorable effect on the histopathological change of the pancreas in diabetic rat groups. Phenolic compounds, as identified by LC-MS/MS, have interacted with 115 unique target proteins. In conclusion, the current results suggest the usefulness of the plant extract as an effective adjuvant antidiabetic agent.http://www.sciencedirect.com/science/article/pii/S2666154325002625Diabetes mellitusSchimpera arabicaRed blood cellsWhite blood cellsPhenolic compounds |
| spellingShingle | Eman R. Elsharkawy Ali Alqahtani Md Nazim Uddin Forhad Khan Yong He Xiaoli Li Mostafa M. Gouda The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats Journal of Agriculture and Food Research Diabetes mellitus Schimpera arabica Red blood cells White blood cells Phenolic compounds |
| title | The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats |
| title_full | The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats |
| title_fullStr | The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats |
| title_full_unstemmed | The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats |
| title_short | The antidiabetic, haematological, and antioxidant implications of Schimpera arabica natural plant on Streptozotocin-diabetic rats |
| title_sort | antidiabetic haematological and antioxidant implications of schimpera arabica natural plant on streptozotocin diabetic rats |
| topic | Diabetes mellitus Schimpera arabica Red blood cells White blood cells Phenolic compounds |
| url | http://www.sciencedirect.com/science/article/pii/S2666154325002625 |
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