<i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation
The genus <i>Seseli</i> L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, <i>Seseli foliosum</i> (Somm. et Levier) Manden., is notable for its unique pharmacological properties. To our knowledge, comprehensive phyt...
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2025-02-01
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| author | Mariam Nersezashvili Dali Berashvili Malkhaz Jokhadze Mariam Metreveli Łukasz Świątek Kinga Salwa Łukasz Pecio Krzysztof Kamil Wojtanowski Adrianna Skiba Izabela Korona-Głowniak Gökhan Zengin Krystyna Skalicka-Woźniak |
| author_facet | Mariam Nersezashvili Dali Berashvili Malkhaz Jokhadze Mariam Metreveli Łukasz Świątek Kinga Salwa Łukasz Pecio Krzysztof Kamil Wojtanowski Adrianna Skiba Izabela Korona-Głowniak Gökhan Zengin Krystyna Skalicka-Woźniak |
| author_sort | Mariam Nersezashvili |
| collection | DOAJ |
| description | The genus <i>Seseli</i> L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, <i>Seseli foliosum</i> (Somm. et Levier) Manden., is notable for its unique pharmacological properties. To our knowledge, comprehensive phytochemical and biological investigations have not yet been conducted. The primary aim of this research is to explore the chemical and biological properties of <i>S. foliosum</i>, thereby enhancing its potential applications in medicine and related fields. Different chromatographic techniques were utilized to isolate individual compounds and to identify the chemical composition of <i>S. foliosum</i> MeOH and Et<sub>2</sub>O extracts from seeds and roots. A battery of biological assays (antimicrobial, antioxidant, enzymatic, anxiolytic, and cytotoxic) were employed to assess the pharmacological properties of the extracts. The results from gas chromatography with mass spectrometry (GC/MS) revealed that both MeOH and Et<sub>2</sub>O extracts contain a diverse array of compounds, including monoterpenoids, sesquiterpenoids, and phenolic compounds. Furanocoumarin edultin was isolated from the MeOH extract by liquid–liquid separation (LLS). The MeOH extracts exhibited important antioxidant, enzyme inhibitory, and antimicrobial activities with notable efficacy against <i>Staphylococcus aureus</i> (MIC 125 µg/mL) and <i>Candida glabrata</i> (MIC 62.5 µg/mL). Underground Et<sub>2</sub>O extracts showed advanced cytotoxic activity, particularly against hypopharyngeal carcinoma cells (CC<sub>50</sub> 22.33 µg/mL and 27.16 µg/mL, respectively). The study provides a wide-range analysis of the phytochemical composition and biological activities of <i>S. foliosum</i>, highlighting its potential as a source of bioactive compounds. These findings contribute to the understanding of the therapeutic potential of <i>S. foliosum</i> and lay the groundwork for further pharmacological and clinical research. |
| format | Article |
| id | doaj-art-792bd2f9d8d44031903febf754679fd9 |
| institution | DOAJ |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| spelling | doaj-art-792bd2f9d8d44031903febf754679fd92025-08-20T03:12:35ZengMDPI AGMolecules1420-30492025-02-0130372510.3390/molecules30030725<i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological EvaluationMariam Nersezashvili0Dali Berashvili1Malkhaz Jokhadze2Mariam Metreveli3Łukasz Świątek4Kinga Salwa5Łukasz Pecio6Krzysztof Kamil Wojtanowski7Adrianna Skiba8Izabela Korona-Głowniak9Gökhan Zengin10Krystyna Skalicka-Woźniak11Direction of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Tbilisi State Medical University, Tbilisi 0186, GeorgiaDirection of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Tbilisi State Medical University, Tbilisi 0186, GeorgiaDirection of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmacy, Tbilisi State Medical University, Tbilisi 0186, GeorgiaInstitute of Phytopathology and Biodiversity, Batumi Shota Rustaveli State University, Batumi 6010, GeorgiaDepartment of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Virology with Viral Diagnostics Laboratory, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Pharmacognosy with Medicinal Plant Garden, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Pharmaceutical Microbiology, Medical University of Lublin, 20-093 Lublin, PolandDepartment of Biology, Faculty of Science, Selcuk University, Konya 42130, TurkeyDepartment of Natural Products Chemistry, Medical University of Lublin, 20-093 Lublin, PolandThe genus <i>Seseli</i> L. (Apiaceae family) is widespread across Europe and Asia, with ten species identified in Georgia. Among these, <i>Seseli foliosum</i> (Somm. et Levier) Manden., is notable for its unique pharmacological properties. To our knowledge, comprehensive phytochemical and biological investigations have not yet been conducted. The primary aim of this research is to explore the chemical and biological properties of <i>S. foliosum</i>, thereby enhancing its potential applications in medicine and related fields. Different chromatographic techniques were utilized to isolate individual compounds and to identify the chemical composition of <i>S. foliosum</i> MeOH and Et<sub>2</sub>O extracts from seeds and roots. A battery of biological assays (antimicrobial, antioxidant, enzymatic, anxiolytic, and cytotoxic) were employed to assess the pharmacological properties of the extracts. The results from gas chromatography with mass spectrometry (GC/MS) revealed that both MeOH and Et<sub>2</sub>O extracts contain a diverse array of compounds, including monoterpenoids, sesquiterpenoids, and phenolic compounds. Furanocoumarin edultin was isolated from the MeOH extract by liquid–liquid separation (LLS). The MeOH extracts exhibited important antioxidant, enzyme inhibitory, and antimicrobial activities with notable efficacy against <i>Staphylococcus aureus</i> (MIC 125 µg/mL) and <i>Candida glabrata</i> (MIC 62.5 µg/mL). Underground Et<sub>2</sub>O extracts showed advanced cytotoxic activity, particularly against hypopharyngeal carcinoma cells (CC<sub>50</sub> 22.33 µg/mL and 27.16 µg/mL, respectively). The study provides a wide-range analysis of the phytochemical composition and biological activities of <i>S. foliosum</i>, highlighting its potential as a source of bioactive compounds. These findings contribute to the understanding of the therapeutic potential of <i>S. foliosum</i> and lay the groundwork for further pharmacological and clinical research.https://www.mdpi.com/1420-3049/30/3/725coumarinvolatilesbacteriafungicytotoxicityantioxidant |
| spellingShingle | Mariam Nersezashvili Dali Berashvili Malkhaz Jokhadze Mariam Metreveli Łukasz Świątek Kinga Salwa Łukasz Pecio Krzysztof Kamil Wojtanowski Adrianna Skiba Izabela Korona-Głowniak Gökhan Zengin Krystyna Skalicka-Woźniak <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation Molecules coumarin volatiles bacteria fungi cytotoxicity antioxidant |
| title | <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation |
| title_full | <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation |
| title_fullStr | <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation |
| title_full_unstemmed | <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation |
| title_short | <i>Seseli foliosum</i> (Somm. et Levier) Manden.—A Comprehensive Phytochemical and Biological Evaluation |
| title_sort | i seseli foliosum i somm et levier manden a comprehensive phytochemical and biological evaluation |
| topic | coumarin volatiles bacteria fungi cytotoxicity antioxidant |
| url | https://www.mdpi.com/1420-3049/30/3/725 |
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