Druggability Studies of Benzene Sulfonamide Substituted Diarylamide (E3) as a Novel Diuretic

Druggability Studies of Benzene Sulfonamide Substituted Diarylamide (E3) as a Novel Diuretic

<b>Background/Objectives</b>: Urea transporters (UTs) play an important role in the urine-concentrating mechanism and have been regarded as a novel drug target for developing salt-sparing diuretics. Our previous studies found that diarylamides 1H and 25a are specific UT inhibitors and ha...

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Bibliographic Details
Main Authors: Hang Zhang, Shuyuan Wang, Nannan Li, Yue Xu, Zhizhen Huang, Yukun Zhang, Jing Li, Yinglin Zuo, Min Li, Runtao Li, Baoxue Yang
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomedicines
Subjects:
urea transporter inhibitor
diuretic
structure optimization
pharmacokinetic
safety evaluation
hyponatremia
Online Access:https://www.mdpi.com/2227-9059/13/4/992
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