Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis

Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis

Abstract Fibroblast-like synoviocytes (FLS) contribute significantly to the pathogenesis of rheumatoid arthritis (RA), particularly through their roles in synovitis and joint destruction. The microRNAs (miRNAs) are short non-coding RNA that regulate gene expression post-transcriptionally. Although m...

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Bibliographic Details
Main Authors: Kei Araki, Sho Mokuda, Hiroki Kohno, Naoya Oka, Hirofumi Watanabe, Michinori Ishitoku, Tomohiro Sugimoto, Yusuke Yoshida, Junya Masumoto, Shintaro Hirata
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
Fibroblast-like synoviocytes
microRNA
hsa-miR-21-5p
Next-generation sequencing
Online Access:https://doi.org/10.1038/s41598-025-02840-z
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