Estrogens as Antioxidant Modulators in Human Fertility
Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/607939 |
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| author | A. Mancini S. Raimondo M. Persano C. Di Segni M. Cammarano G. Gadotti A. Silvestrini A. Pontecorvi E. Meucci |
| author_facet | A. Mancini S. Raimondo M. Persano C. Di Segni M. Cammarano G. Gadotti A. Silvestrini A. Pontecorvi E. Meucci |
| author_sort | A. Mancini |
| collection | DOAJ |
| description | Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants. |
| format | Article |
| id | doaj-art-7924e2d7d50f48cc9399aab609abccaf |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-7924e2d7d50f48cc9399aab609abccaf2025-02-03T00:59:10ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/607939607939Estrogens as Antioxidant Modulators in Human FertilityA. Mancini0S. Raimondo1M. Persano2C. Di Segni3M. Cammarano4G. Gadotti5A. Silvestrini6A. Pontecorvi7E. Meucci8Division of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyInstitute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, ItalyDivision of Endocrinology, Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, ItalyInstitute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, ItalyAmong treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.http://dx.doi.org/10.1155/2013/607939 |
| spellingShingle | A. Mancini S. Raimondo M. Persano C. Di Segni M. Cammarano G. Gadotti A. Silvestrini A. Pontecorvi E. Meucci Estrogens as Antioxidant Modulators in Human Fertility International Journal of Endocrinology |
| title | Estrogens as Antioxidant Modulators in Human Fertility |
| title_full | Estrogens as Antioxidant Modulators in Human Fertility |
| title_fullStr | Estrogens as Antioxidant Modulators in Human Fertility |
| title_full_unstemmed | Estrogens as Antioxidant Modulators in Human Fertility |
| title_short | Estrogens as Antioxidant Modulators in Human Fertility |
| title_sort | estrogens as antioxidant modulators in human fertility |
| url | http://dx.doi.org/10.1155/2013/607939 |
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