Advances of therapeutic microbubbles and nanobubbles
As versatile nanotools, microbubbles (MBs) and nanobubbles (NBs) have gained increasing attention because of their great potentials for therapeutic applications. The filled gases can greatly influence the physical properties of the MBs and NBs, such as size, zeta potential, and stability. Importantl...
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| Format: | Article |
| Language: | English |
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Science Press
2023-08-01
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| Series: | National Science Open |
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| Online Access: | https://www.sciengine.com/doi/10.1360/nso/20220062 |
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| author | Huang Bin Yang Li Yu Wenbing Li Yan Li Ling Gu Ning |
| author_facet | Huang Bin Yang Li Yu Wenbing Li Yan Li Ling Gu Ning |
| author_sort | Huang Bin |
| collection | DOAJ |
| description | As versatile nanotools, microbubbles (MBs) and nanobubbles (NBs) have gained increasing attention because of their great potentials for therapeutic applications. The filled gases can greatly influence the physical properties of the MBs and NBs, such as size, zeta potential, and stability. Importantly, the biological activity of the filled gases plays a key role in the therapeutic effect of MBs and NBs. In this review, we will introduce the background, classification, and design strategies of therapeutic MBs and NBs based on bio-active and bio-inactive gases. Furthermore, focus will be placed on the biomedical applications in cancer treatments, including drug delivery, targeting effect and combinations of different therapeutic modalities. Finally, we will discuss the remaining challenges and future perspectives of therapeutic MBs and NBs. |
| format | Article |
| id | doaj-art-7924842151be4ea8bb91a1ebc8e0acbc |
| institution | DOAJ |
| issn | 2097-1168 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Science Press |
| record_format | Article |
| series | National Science Open |
| spelling | doaj-art-7924842151be4ea8bb91a1ebc8e0acbc2025-08-20T02:47:08ZengScience PressNational Science Open2097-11682023-08-01210.1360/nso/20220062eb33e642Advances of therapeutic microbubbles and nanobubblesHuang Bin0Yang Li1Yu Wenbing2Li Yan3Li Ling4Gu Ning5["State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China"]["Zhongda Hospital, Southeast University, Nanjing 210096, China"]["State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"]["State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"]["Zhongda Hospital, Southeast University, Nanjing 210096, China"]["State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China","Medical School, Nanjing University, Nanjing 210093, China"]As versatile nanotools, microbubbles (MBs) and nanobubbles (NBs) have gained increasing attention because of their great potentials for therapeutic applications. The filled gases can greatly influence the physical properties of the MBs and NBs, such as size, zeta potential, and stability. Importantly, the biological activity of the filled gases plays a key role in the therapeutic effect of MBs and NBs. In this review, we will introduce the background, classification, and design strategies of therapeutic MBs and NBs based on bio-active and bio-inactive gases. Furthermore, focus will be placed on the biomedical applications in cancer treatments, including drug delivery, targeting effect and combinations of different therapeutic modalities. Finally, we will discuss the remaining challenges and future perspectives of therapeutic MBs and NBs.https://www.sciengine.com/doi/10.1360/nso/20220062microbubblesnanobubblesgascancer treatmentultrasound |
| spellingShingle | Huang Bin Yang Li Yu Wenbing Li Yan Li Ling Gu Ning Advances of therapeutic microbubbles and nanobubbles National Science Open microbubbles nanobubbles gas cancer treatment ultrasound |
| title | Advances of therapeutic microbubbles and nanobubbles |
| title_full | Advances of therapeutic microbubbles and nanobubbles |
| title_fullStr | Advances of therapeutic microbubbles and nanobubbles |
| title_full_unstemmed | Advances of therapeutic microbubbles and nanobubbles |
| title_short | Advances of therapeutic microbubbles and nanobubbles |
| title_sort | advances of therapeutic microbubbles and nanobubbles |
| topic | microbubbles nanobubbles gas cancer treatment ultrasound |
| url | https://www.sciengine.com/doi/10.1360/nso/20220062 |
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