Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires
The aim of the study was to compare the side effects of high-dose-rate brachytherapy (HDRBT) and low-dose-rate brachytherapy (LDRBT), with a particular focus on the effects on sexual functions and sexual well-being (PROMOBRA study, NCT02258087). Localized low-risk and low-intermediate-risk prostate...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2024/5729185 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548334648164352 |
|---|---|
| author | László Gesztesi Zsuzsa S. Kocsis Kliton Jorgo Georgina Fröhlich Csaba Polgár Péter Ágoston |
| author_facet | László Gesztesi Zsuzsa S. Kocsis Kliton Jorgo Georgina Fröhlich Csaba Polgár Péter Ágoston |
| author_sort | László Gesztesi |
| collection | DOAJ |
| description | The aim of the study was to compare the side effects of high-dose-rate brachytherapy (HDRBT) and low-dose-rate brachytherapy (LDRBT), with a particular focus on the effects on sexual functions and sexual well-being (PROMOBRA study, NCT02258087). Localized low-risk and low-intermediate-risk prostate cancer patients were treated with mono LDR (N = 123, 145 Gy dose) or mono HDR brachytherapy (N = 117, 19/21 Gy). Prior to the treatment and during follow-up (at 3, 6, 9, 12, 18, and 24 months after treatment, and then annually after two years), patients completed patient-reported outcome measurement (PROM) questionnaires EORTC QLQ-PR-25, International Index of Erectile Function (IIEF), and IIEF-5 (SHIM). We compared the patients in different group breakdowns (HDR vs. LDR, hormone naïve and hormone-receiving HDR vs. LDR, hormone naïve and hormone-receiving patients in general, and 19 Gy HDR vs. 21 Gy HDR). In the hormone-naive LDR group, erectile function, orgasm function, sexual desire, satisfaction with intercourse, and overall satisfaction functions significantly decreased compared to baseline throughout the whole follow-up period. However, there were significant decreases in function at a maximum of three time points after HDR therapy without hormone therapy. In hormone-receiving patients, the orgasm function was significantly better in the HDR group at multiple time points compared to the baseline, and sexual desire improved at four time points. According to our results, both LDRBT and HDRBT can be safely administered to patients with localized prostate cancer. In hormone-naive patients, the HDR group showed only recovering decreases in sexual functions, while the LDR group showed a lasting decline in multiple areas. Thus, HDR appears to be more advantageous to hormone-naive patients. |
| format | Article |
| id | doaj-art-79247b246cef45f1a07aa7d0d8a80827 |
| institution | Kabale University |
| issn | 2090-312X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-79247b246cef45f1a07aa7d0d8a808272025-02-03T06:14:52ZengWileyProstate Cancer2090-312X2024-01-01202410.1155/2024/5729185Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported QuestionnairesLászló Gesztesi0Zsuzsa S. Kocsis1Kliton Jorgo2Georgina Fröhlich3Csaba Polgár4Péter Ágoston5National Institute of OncologyNational Institute of OncologyNational Institute of OncologyNational Institute of OncologyNational Institute of OncologyNational Institute of OncologyThe aim of the study was to compare the side effects of high-dose-rate brachytherapy (HDRBT) and low-dose-rate brachytherapy (LDRBT), with a particular focus on the effects on sexual functions and sexual well-being (PROMOBRA study, NCT02258087). Localized low-risk and low-intermediate-risk prostate cancer patients were treated with mono LDR (N = 123, 145 Gy dose) or mono HDR brachytherapy (N = 117, 19/21 Gy). Prior to the treatment and during follow-up (at 3, 6, 9, 12, 18, and 24 months after treatment, and then annually after two years), patients completed patient-reported outcome measurement (PROM) questionnaires EORTC QLQ-PR-25, International Index of Erectile Function (IIEF), and IIEF-5 (SHIM). We compared the patients in different group breakdowns (HDR vs. LDR, hormone naïve and hormone-receiving HDR vs. LDR, hormone naïve and hormone-receiving patients in general, and 19 Gy HDR vs. 21 Gy HDR). In the hormone-naive LDR group, erectile function, orgasm function, sexual desire, satisfaction with intercourse, and overall satisfaction functions significantly decreased compared to baseline throughout the whole follow-up period. However, there were significant decreases in function at a maximum of three time points after HDR therapy without hormone therapy. In hormone-receiving patients, the orgasm function was significantly better in the HDR group at multiple time points compared to the baseline, and sexual desire improved at four time points. According to our results, both LDRBT and HDRBT can be safely administered to patients with localized prostate cancer. In hormone-naive patients, the HDR group showed only recovering decreases in sexual functions, while the LDR group showed a lasting decline in multiple areas. Thus, HDR appears to be more advantageous to hormone-naive patients.http://dx.doi.org/10.1155/2024/5729185 |
| spellingShingle | László Gesztesi Zsuzsa S. Kocsis Kliton Jorgo Georgina Fröhlich Csaba Polgár Péter Ágoston Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires Prostate Cancer |
| title | Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires |
| title_full | Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires |
| title_fullStr | Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires |
| title_full_unstemmed | Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires |
| title_short | Alterations of Sexual and Erectile Functions after Brachytherapy for Prostate Cancer Based on Patient-Reported Questionnaires |
| title_sort | alterations of sexual and erectile functions after brachytherapy for prostate cancer based on patient reported questionnaires |
| url | http://dx.doi.org/10.1155/2024/5729185 |
| work_keys_str_mv | AT laszlogesztesi alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires AT zsuzsaskocsis alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires AT klitonjorgo alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires AT georginafrohlich alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires AT csabapolgar alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires AT peteragoston alterationsofsexualanderectilefunctionsafterbrachytherapyforprostatecancerbasedonpatientreportedquestionnaires |