The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia
Hyperreactio luteinalis (HL) is a rare condition that presents as bilateral ovarian enlargement during pregnancy. Typically, it is thought to be caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. The progno...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2023/7352947 |
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| author | Risa Miyatake Tatsuya Fujii Keiichi Kumasawa Mari Ichinose Masatake Toshimitsu Seisuke Sayama Takahiro Seyama Takayuki Iriyama Takeshi Nagamatsu Yutaka Osuga |
| author_facet | Risa Miyatake Tatsuya Fujii Keiichi Kumasawa Mari Ichinose Masatake Toshimitsu Seisuke Sayama Takahiro Seyama Takayuki Iriyama Takeshi Nagamatsu Yutaka Osuga |
| author_sort | Risa Miyatake |
| collection | DOAJ |
| description | Hyperreactio luteinalis (HL) is a rare condition that presents as bilateral ovarian enlargement during pregnancy. Typically, it is thought to be caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. The prognosis is relatively good, with many cases resulting in term birth. However, some obstetric complications, such as preeclampsia (PE) and preterm births, have been reported. We present a serious case of HL with subsequent PE that resulted in preterm delivery at 31 weeks of gestation. The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio was very high at the onset of PE at 24 weeks of gestation, followed by a modest decline, which then increased in proportion to the exacerbation of symptoms. Since HL cases have also been reported to be associated with PE, repeated measurement of the sFlt-1/PlGF ratio proved useful for better pregnancy management. |
| format | Article |
| id | doaj-art-7922b4a6d28e4278aa451343b1b001fd |
| institution | OA Journals |
| issn | 2090-6692 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-7922b4a6d28e4278aa451343b1b001fd2025-08-20T02:07:31ZengWileyCase Reports in Obstetrics and Gynecology2090-66922023-01-01202310.1155/2023/7352947The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with PreeclampsiaRisa Miyatake0Tatsuya Fujii1Keiichi Kumasawa2Mari Ichinose3Masatake Toshimitsu4Seisuke Sayama5Takahiro Seyama6Takayuki Iriyama7Takeshi Nagamatsu8Yutaka Osuga9Department of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyDepartment of Obstetrics and GynecologyHyperreactio luteinalis (HL) is a rare condition that presents as bilateral ovarian enlargement during pregnancy. Typically, it is thought to be caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. The prognosis is relatively good, with many cases resulting in term birth. However, some obstetric complications, such as preeclampsia (PE) and preterm births, have been reported. We present a serious case of HL with subsequent PE that resulted in preterm delivery at 31 weeks of gestation. The soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor (PlGF) ratio was very high at the onset of PE at 24 weeks of gestation, followed by a modest decline, which then increased in proportion to the exacerbation of symptoms. Since HL cases have also been reported to be associated with PE, repeated measurement of the sFlt-1/PlGF ratio proved useful for better pregnancy management.http://dx.doi.org/10.1155/2023/7352947 |
| spellingShingle | Risa Miyatake Tatsuya Fujii Keiichi Kumasawa Mari Ichinose Masatake Toshimitsu Seisuke Sayama Takahiro Seyama Takayuki Iriyama Takeshi Nagamatsu Yutaka Osuga The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia Case Reports in Obstetrics and Gynecology |
| title | The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia |
| title_full | The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia |
| title_fullStr | The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia |
| title_full_unstemmed | The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia |
| title_short | The sFlt-1/PlGF Ratio Trend Is Useful in Predicting Preeclampsia Severity in Hyperreactio Luteinalis Complicated with Preeclampsia |
| title_sort | sflt 1 plgf ratio trend is useful in predicting preeclampsia severity in hyperreactio luteinalis complicated with preeclampsia |
| url | http://dx.doi.org/10.1155/2023/7352947 |
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