Antimelanoma and Antityrosinase from Alpinia galangal Constituents
Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/186505 |
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| author | Chih-Yu Lo Po-Len Liu Li-Ching Lin Yen-Ting Chen You-Cheng Hseu Zhi-Hong Wen Hui-Min Wang |
| author_facet | Chih-Yu Lo Po-Len Liu Li-Ching Lin Yen-Ting Chen You-Cheng Hseu Zhi-Hong Wen Hui-Min Wang |
| author_sort | Chih-Yu Lo |
| collection | DOAJ |
| description | Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry. |
| format | Article |
| id | doaj-art-7918d6afde704479a5e7c602935f1fb4 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-7918d6afde704479a5e7c602935f1fb42025-02-03T01:20:50ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/186505186505Antimelanoma and Antityrosinase from Alpinia galangal ConstituentsChih-Yu Lo0Po-Len Liu1Li-Ching Lin2Yen-Ting Chen3You-Cheng Hseu4Zhi-Hong Wen5Hui-Min Wang6Department of Food Science, National Chiayi University, Chiayi 60083, TaiwanDepartment of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, TaiwanDepartment of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 40402, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, TaiwanTwo compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.http://dx.doi.org/10.1155/2013/186505 |
| spellingShingle | Chih-Yu Lo Po-Len Liu Li-Ching Lin Yen-Ting Chen You-Cheng Hseu Zhi-Hong Wen Hui-Min Wang Antimelanoma and Antityrosinase from Alpinia galangal Constituents The Scientific World Journal |
| title | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
| title_full | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
| title_fullStr | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
| title_full_unstemmed | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
| title_short | Antimelanoma and Antityrosinase from Alpinia galangal Constituents |
| title_sort | antimelanoma and antityrosinase from alpinia galangal constituents |
| url | http://dx.doi.org/10.1155/2013/186505 |
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