Inhibition of GSK-3β Restores Differentiation Potential of Late-Passage Mesenchymal Stem Cells

Inhibition of GSK-3β Restores Differentiation Potential of Late-Passage Mesenchymal Stem Cells

<b>Background/Objectives:</b> Mesenchymal stem cells (MSCs) are regarded as a promising cell type with significant therapeutic benefits owing to their ease of isolation, maintenance, and characterisation. However, repeated passages during cultural maintenance frequently result in cellula...

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Main Authors: Kavitha Govarthanan, Raja Sundari Meenakshi Sundaram, Arthi Sunil Richard, Siva Chander Chabathula, Secunda Rupert, Jeswanth Sathyanesan, Rama Shanker Verma, Naveen Jeyaraman, Madhan Jeyaraman, Ramya Lakshmi Rajendran, Prakash Gangadaran, Byeong-Cheol Ahn
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceuticals
Subjects:
MSCs
senescence
rejuvenation
CHIR 99021
tri-lineage
differentiation
Online Access:https://www.mdpi.com/1424-8247/18/4/483
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