Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.

Chemokine receptor Ccr1 drives neutrophil-mediated kidney immunopathology and mortality in invasive candidiasis.

Invasive candidiasis is the 4(th) leading cause of nosocomial bloodstream infection in the US with mortality that exceeds 40% despite administration of antifungal therapy; neutropenia is a major risk factor for poor outcome after invasive candidiasis. In a fatal mouse model of invasive candidiasis t...

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Bibliographic Details
Main Authors: Michail S Lionakis, Brett G Fischer, Jean K Lim, Muthulekha Swamydas, Wuzhou Wan, Chyi-Chia Richard Lee, Jeffrey I Cohen, Phillip Scheinberg, Ji-Liang Gao, Philip M Murphy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002865&type=printable
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