Obsessive-compulsive disorder and temporal lobe porencephaly: a case report
Abstract Background The functional and structural abnormalities of cortico-striato-thalamo-cortex have been reported to be associated with the neurobiological basis of obsessive–compulsive disorder (OCD). OCD can also occur in the striatum damaging after brain infarction, which is called OCD caused...
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2025-04-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-06774-8 |
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| author | Gaoju Deng Yuan Cao Changjian Qiu |
| author_facet | Gaoju Deng Yuan Cao Changjian Qiu |
| author_sort | Gaoju Deng |
| collection | DOAJ |
| description | Abstract Background The functional and structural abnormalities of cortico-striato-thalamo-cortex have been reported to be associated with the neurobiological basis of obsessive–compulsive disorder (OCD). OCD can also occur in the striatum damaging after brain infarction, which is called OCD caused by physical diseases. The relationship and mechanism between temporal lobe abnormalities and OCD are still unclear. Case presentation A young male with temporal lobe porencephaly presented with obsessive–compulsive symptoms. The cognition of this OCD participant was not significantly impaired, and his social function was well maintained. After treatment with sertraline, aripiprazole, and fluvoxamine, he was improved but relapsed several times after drug withdrawal. However, the therapeutic effect was sustained upon reinitiation of the medication. Conclusion This is the first reported case of OCD in an individual with left temporal lobe porencephaly. The possible relationship between obsessive–compulsive symptoms and temporal lobe structural abnormalities needs to be further studied. The maintenance treatment and prognosis of organic obsessive–compulsive disorder also deserve further study. |
| format | Article |
| id | doaj-art-7907d304ea28481cbc65e1b22f3d5380 |
| institution | DOAJ |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj-art-7907d304ea28481cbc65e1b22f3d53802025-08-20T03:06:50ZengBMCBMC Psychiatry1471-244X2025-04-012511610.1186/s12888-025-06774-8Obsessive-compulsive disorder and temporal lobe porencephaly: a case reportGaoju Deng0Yuan Cao1Changjian Qiu2Mental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental DisordersMental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental DisordersMental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental DisordersAbstract Background The functional and structural abnormalities of cortico-striato-thalamo-cortex have been reported to be associated with the neurobiological basis of obsessive–compulsive disorder (OCD). OCD can also occur in the striatum damaging after brain infarction, which is called OCD caused by physical diseases. The relationship and mechanism between temporal lobe abnormalities and OCD are still unclear. Case presentation A young male with temporal lobe porencephaly presented with obsessive–compulsive symptoms. The cognition of this OCD participant was not significantly impaired, and his social function was well maintained. After treatment with sertraline, aripiprazole, and fluvoxamine, he was improved but relapsed several times after drug withdrawal. However, the therapeutic effect was sustained upon reinitiation of the medication. Conclusion This is the first reported case of OCD in an individual with left temporal lobe porencephaly. The possible relationship between obsessive–compulsive symptoms and temporal lobe structural abnormalities needs to be further studied. The maintenance treatment and prognosis of organic obsessive–compulsive disorder also deserve further study.https://doi.org/10.1186/s12888-025-06774-8Obsessive-compulsive disorderTemporal lobePorencephaly |
| spellingShingle | Gaoju Deng Yuan Cao Changjian Qiu Obsessive-compulsive disorder and temporal lobe porencephaly: a case report BMC Psychiatry Obsessive-compulsive disorder Temporal lobe Porencephaly |
| title | Obsessive-compulsive disorder and temporal lobe porencephaly: a case report |
| title_full | Obsessive-compulsive disorder and temporal lobe porencephaly: a case report |
| title_fullStr | Obsessive-compulsive disorder and temporal lobe porencephaly: a case report |
| title_full_unstemmed | Obsessive-compulsive disorder and temporal lobe porencephaly: a case report |
| title_short | Obsessive-compulsive disorder and temporal lobe porencephaly: a case report |
| title_sort | obsessive compulsive disorder and temporal lobe porencephaly a case report |
| topic | Obsessive-compulsive disorder Temporal lobe Porencephaly |
| url | https://doi.org/10.1186/s12888-025-06774-8 |
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