Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers

Protocol of a randomized, single-blind, controlled trial of an 18-month, home-based, high-intensity, exercise intervention in older, cognitively unimpaired APOE ε4 carriers

BackgroundThe World Health Organization highlighted the potential protective role of exercise against cognitive decline, all-cause dementia, Alzheimer’s disease (AD), and vascular dementia in healthy individuals. We have previously shown that exercise is particularly beneficial for older, cognitivel...

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Main Authors: Stephen M. Rao, Alexandria L. Chorba, M. J. Helppi, Alina Tuladhar, Amanda L. Penko, Sarah Holley, Brandon Nehls, Sabrina Paulino, Matthew C. Streicher, Audrey Zhu, Kellie Bruening, Sally Durgerian, Katherine Koenig, Mark Lowe, Wanyong Shin, Stephen E. Jones, Rachel Galioto, Jagan A. Pillai, Lynn M. Bekris, James B. Leverenz, Anson B. Rosenfeldt, Tamanna Singh, Gerald J. Beck, J. Carson Smith, Jay Alberts
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
exercise
neuroprotection
APOE ε4
randomized clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1584115/full
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