Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines
Pathogenic flaviviruses are predominantly the pathogens of emerging and re-emerging infectious diseases, which have caused multiple public health emergencies globally and pose a serious threat to human health and social development. Although significant achievements have been made in vaccine researc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/7/769 |
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| author | Jia-Zhen Cui Xiang-Hua Xiong Qing-Yang Wang Hao-Long Dong Gang Liu Hui-Peng Chen |
| author_facet | Jia-Zhen Cui Xiang-Hua Xiong Qing-Yang Wang Hao-Long Dong Gang Liu Hui-Peng Chen |
| author_sort | Jia-Zhen Cui |
| collection | DOAJ |
| description | Pathogenic flaviviruses are predominantly the pathogens of emerging and re-emerging infectious diseases, which have caused multiple public health emergencies globally and pose a serious threat to human health and social development. Although significant achievements have been made in vaccine research, issues such as limited protective effects and virulence reversion persist, making the development of novel vaccines against pathogenic flaviviruses a current research hotspot and challenge. ISFVs have recently attracted attention due to their high homology with pathogenic flaviviruses and unique inability to replicate in mammalian hosts. Multiple vaccine candidate strains constructed using ISFVs as scaffolds have demonstrated excellent safety and efficacy. This review summarizes the biological characteristics, host restriction factors, current applications in vaccine development, and challenges faced by ISFVs, providing a reference for future research on pathogenic flavivirus vaccines. |
| format | Article |
| id | doaj-art-7904e9be985343329bd6fc9d07b08ae2 |
| institution | DOAJ |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-7904e9be985343329bd6fc9d07b08ae22025-08-20T03:13:54ZengMDPI AGVaccines2076-393X2025-07-0113776910.3390/vaccines13070769Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus VaccinesJia-Zhen Cui0Xiang-Hua Xiong1Qing-Yang Wang2Hao-Long Dong3Gang Liu4Hui-Peng Chen5Academy of Military Medical Sciences, Beijing 100850, ChinaAcademy of Military Medical Sciences, Beijing 100850, ChinaAcademy of Military Medical Sciences, Beijing 100850, ChinaAcademy of Military Medical Sciences, Beijing 100850, ChinaAcademy of Military Medical Sciences, Beijing 100850, ChinaAcademy of Military Medical Sciences, Beijing 100850, ChinaPathogenic flaviviruses are predominantly the pathogens of emerging and re-emerging infectious diseases, which have caused multiple public health emergencies globally and pose a serious threat to human health and social development. Although significant achievements have been made in vaccine research, issues such as limited protective effects and virulence reversion persist, making the development of novel vaccines against pathogenic flaviviruses a current research hotspot and challenge. ISFVs have recently attracted attention due to their high homology with pathogenic flaviviruses and unique inability to replicate in mammalian hosts. Multiple vaccine candidate strains constructed using ISFVs as scaffolds have demonstrated excellent safety and efficacy. This review summarizes the biological characteristics, host restriction factors, current applications in vaccine development, and challenges faced by ISFVs, providing a reference for future research on pathogenic flavivirus vaccines.https://www.mdpi.com/2076-393X/13/7/769insect-specific flavivirusvaccine scaffoldpathogenic flavivirusvaccine developmenthost restriction |
| spellingShingle | Jia-Zhen Cui Xiang-Hua Xiong Qing-Yang Wang Hao-Long Dong Gang Liu Hui-Peng Chen Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines Vaccines insect-specific flavivirus vaccine scaffold pathogenic flavivirus vaccine development host restriction |
| title | Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines |
| title_full | Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines |
| title_fullStr | Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines |
| title_full_unstemmed | Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines |
| title_short | Insect-Specific Flaviviruses Have Potential Applications as a Scaffold for Pathogenic Flavivirus Vaccines |
| title_sort | insect specific flaviviruses have potential applications as a scaffold for pathogenic flavivirus vaccines |
| topic | insect-specific flavivirus vaccine scaffold pathogenic flavivirus vaccine development host restriction |
| url | https://www.mdpi.com/2076-393X/13/7/769 |
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