The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesis

The swine acute diarrhea syndrome coronavirus spike protein promotes syncytial formation via upregulation of cellular cholesterol synthesis

ABSTRACT Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel coronavirus that causes acute diarrhea, vomiting, and high mortality in suckling piglets. Research has demonstrated that certain viruses enhance their replication by modulating intracellular cholesterol metabolism. However, the...

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Main Authors: Dakai Liu, Miaomiao Zeng, Jiyu Zhang, Liaoyuan Zhang, Hongyan Shi, Xin Zhang, Jialin Zhang, Jianfei Chen, Zhaoyang Ji, Xiuwen Li, Gengting Gu, Tingshuai Feng, Da Shi, Dongbo Sun, Li Feng
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
swine acute diarrhea syndrome coronavirus
cholesterol
spike protein
syncytia
Online Access:https://journals.asm.org/doi/10.1128/mbio.00976-25
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