Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls
Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lun...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nucleic Acids |
| Online Access: | http://dx.doi.org/10.4061/2010/386798 |
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| author | Marco Peluso Armelle Munnia Sara Piro Alessandra Armillis Marcello Ceppi Giuseppe Matullo Riccardo Puntoni |
| author_facet | Marco Peluso Armelle Munnia Sara Piro Alessandra Armillis Marcello Ceppi Giuseppe Matullo Riccardo Puntoni |
| author_sort | Marco Peluso |
| collection | DOAJ |
| description | Smoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls.
When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I. 1.28–13.09, P=.009). A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I. 1.17–1132.84, P=.040). A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I. 0.33–62.93, P=.259). Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases. |
| format | Article |
| id | doaj-art-78fc152dfa03450f9bba4bc1839ef4f7 |
| institution | Kabale University |
| issn | 2090-021X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nucleic Acids |
| spelling | doaj-art-78fc152dfa03450f9bba4bc1839ef4f72025-02-03T01:10:15ZengWileyJournal of Nucleic Acids2090-021X2010-01-01201010.4061/2010/386798386798Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in ControlsMarco Peluso0Armelle Munnia1Sara Piro2Alessandra Armillis3Marcello Ceppi4Giuseppe Matullo5Riccardo Puntoni6Cancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio N.2, 50139 Florence, ItalyCancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio N.2, 50139 Florence, ItalyCancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio N.2, 50139 Florence, ItalyCancer Risk Factor Branch, Analytical and Biomolecular Cytology Unit, ISPO-Cancer Prevention and Research Institute, Via Cosimo il Vecchio N.2, 50139 Florence, ItalyMolecular Epidemiology Unit, National Cancer Research Institute, 16132 Genoa, ItalyDepartment of Genetics, Biology and Biochemistry, Faculty of Medicine and Surgery, University of Turin, 10124 Turin, ItalyMolecular Epidemiology Unit, National Cancer Research Institute, 16132 Genoa, ItalySmoke constituents can induce DNA adducts that cause mutations and lead to lung cancer. We have analyzed DNA adducts and polymorphisms in two DNA repair genes, for example, XRCC1 Arg194Trp and Arg399Gln genes and XRCC3 Thr241Met gene, in 34 lung cancer cases in respect to 30 subjects with benign lung cancer disease and 40 healthy controls. When the study population was categorized in base to the number of risk alleles, adducts were significantly increased in individuals bearing 3-4 risk alleles (OR=4.1 95% C.I. 1.28–13.09, P=.009). A significant association with smoking was noticed in smokers for more than 40 years carrying 3-4 risk alleles (OR=36.38, 95% C.I. 1.17–1132.84, P=.040). A not statistically significant increment of lung cancer risk was observed in the same group (OR=4.54, 95% C.I. 0.33–62.93, P=.259). Our results suggest that the analysis of the number of risk alleles predicts the interindividual variation in DNA adducts of smokers and lung cancer cases.http://dx.doi.org/10.4061/2010/386798 |
| spellingShingle | Marco Peluso Armelle Munnia Sara Piro Alessandra Armillis Marcello Ceppi Giuseppe Matullo Riccardo Puntoni Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls Journal of Nucleic Acids |
| title | Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls |
| title_full | Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls |
| title_fullStr | Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls |
| title_full_unstemmed | Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls |
| title_short | Smoking, DNA Adducts and Number of Risk DNA Repair Alleles in Lung Cancer Cases, in Subjects with Benign Lung Diseases and in Controls |
| title_sort | smoking dna adducts and number of risk dna repair alleles in lung cancer cases in subjects with benign lung diseases and in controls |
| url | http://dx.doi.org/10.4061/2010/386798 |
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