The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies
Abstract Background The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications...
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BMC
2025-08-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-025-01448-2 |
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| author | Yuanyuan Sun Yan Luo Jinyao Ning Yitong Chai Jingjing Chen Fen Xiao Ge Li Xu Zhou Fen Tian Bin Xu Qiong Zhang Hankun Su Jing Zhao Yanping Li Hui Li |
| author_facet | Yuanyuan Sun Yan Luo Jinyao Ning Yitong Chai Jingjing Chen Fen Xiao Ge Li Xu Zhou Fen Tian Bin Xu Qiong Zhang Hankun Su Jing Zhao Yanping Li Hui Li |
| author_sort | Yuanyuan Sun |
| collection | DOAJ |
| description | Abstract Background The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications, it is essential to fully understand the impact of stem cell-derived EVs on IUA. Methods PubMed, EMBASE, Cochrane Library, Web of Science were searched up to May 19th 2025. Trial sequential analysis was conducted to evaluate outcomes, while sensitivity analysis and publication bias assessment were conducted using Stata 14. Results Across 26 studies (899 animals), our analyses have uncovered several important findings as the following: stem cell-derived EVs significantly improved the number of endometrial glands (SMD = 3.78; 95% CI: 2.62 ~ 4.93; P < 0.00001); endometrial thickness (SMD = 2.65; 95% CI: 1.90 ~ 3.40; P < 0.00001) and the number of embryos (SMD = 2.00; 95% CI: 1.02 ~ 2.97; P = 0.0004); fibrosis reduction (SMD = -3.25; 95% CI: -4.24~ -2.26; P < 0.00001) in IUA animal models. EVs downregulated fibrosis markers (TGF-β1, α-SMA, Col-1) and upregulated vascularization (VEGF) and proliferation (Ki67) genes. Conclusions Stem cell-derived EVs demonstrate safety and efficacy in treating IUA animal models, with potential improvements in fertility outcomes. |
| format | Article |
| id | doaj-art-78faef550f6147adb4e5768042bc16ad |
| institution | Kabale University |
| issn | 1477-7827 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj-art-78faef550f6147adb4e5768042bc16ad2025-08-20T03:41:57ZengBMCReproductive Biology and Endocrinology1477-78272025-08-0123112010.1186/s12958-025-01448-2The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studiesYuanyuan Sun0Yan Luo1Jinyao Ning2Yitong Chai3Jingjing Chen4Fen Xiao5Ge Li6Xu Zhou7Fen Tian8Bin Xu9Qiong Zhang10Hankun Su11Jing Zhao12Yanping Li13Hui Li14Department of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityDepartment of Reproductive Medicine, Xiangya Hospital, Central South UniversityAbstract Background The therapeutic potential of stem cell-derived extracellular vesicles (EVs) for intrauterine adhesions (IUA) has attracted increasing preclinical investigation, yet a comprehensive and up-to-date meta-analysis is currently lacking. Before moving forward with clinical applications, it is essential to fully understand the impact of stem cell-derived EVs on IUA. Methods PubMed, EMBASE, Cochrane Library, Web of Science were searched up to May 19th 2025. Trial sequential analysis was conducted to evaluate outcomes, while sensitivity analysis and publication bias assessment were conducted using Stata 14. Results Across 26 studies (899 animals), our analyses have uncovered several important findings as the following: stem cell-derived EVs significantly improved the number of endometrial glands (SMD = 3.78; 95% CI: 2.62 ~ 4.93; P < 0.00001); endometrial thickness (SMD = 2.65; 95% CI: 1.90 ~ 3.40; P < 0.00001) and the number of embryos (SMD = 2.00; 95% CI: 1.02 ~ 2.97; P = 0.0004); fibrosis reduction (SMD = -3.25; 95% CI: -4.24~ -2.26; P < 0.00001) in IUA animal models. EVs downregulated fibrosis markers (TGF-β1, α-SMA, Col-1) and upregulated vascularization (VEGF) and proliferation (Ki67) genes. Conclusions Stem cell-derived EVs demonstrate safety and efficacy in treating IUA animal models, with potential improvements in fertility outcomes.https://doi.org/10.1186/s12958-025-01448-2Intrauterine adhesionsExtracellular vesiclesMeta-analysisTrial sequential analysis |
| spellingShingle | Yuanyuan Sun Yan Luo Jinyao Ning Yitong Chai Jingjing Chen Fen Xiao Ge Li Xu Zhou Fen Tian Bin Xu Qiong Zhang Hankun Su Jing Zhao Yanping Li Hui Li The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies Reproductive Biology and Endocrinology Intrauterine adhesions Extracellular vesicles Meta-analysis Trial sequential analysis |
| title | The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies |
| title_full | The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies |
| title_fullStr | The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies |
| title_full_unstemmed | The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies |
| title_short | The effectiveness of stem cell‑derived extracellular vesicles therapy for intrauterine adhesions: a meta-analysis of preclinical studies |
| title_sort | effectiveness of stem cell derived extracellular vesicles therapy for intrauterine adhesions a meta analysis of preclinical studies |
| topic | Intrauterine adhesions Extracellular vesicles Meta-analysis Trial sequential analysis |
| url | https://doi.org/10.1186/s12958-025-01448-2 |
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