Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment
Abstract MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of circulating miRNAs may parallel the cellular composition and dynamic activity within...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Molecular Cancer |
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| Online Access: | https://doi.org/10.1186/s12943-025-02298-7 |
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| author | Su Yin Lim Suzanah C. Boyd Russell J. Diefenbach Helen Rizos |
| author_facet | Su Yin Lim Suzanah C. Boyd Russell J. Diefenbach Helen Rizos |
| author_sort | Su Yin Lim |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of circulating miRNAs may parallel the cellular composition and dynamic activity within the tumour microenvironment and reveal systemic immune responses. The functional complexity of miRNAs—where a single miRNA can regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, and a single mRNA can be targeted by multiple miRNAs—underscores their broad significance and impact. However, this complexity poses significant challenges for translating miRNA research into clinical practice. In melanoma, specific miRNA signatures have shown notable diagnostic, prognostic and predictive value, with lineage-specific and immune-related miRNAs frequently identified as valuable markers. In this review, we explore the role of circulating miRNAs as potential biomarkers in melanoma, and highlight the current status and advances required to translate miRNA research into therapeutic opportunities. |
| format | Article |
| id | doaj-art-78f98a038b3a4ecbac2829a03d54850a |
| institution | DOAJ |
| issn | 1476-4598 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj-art-78f98a038b3a4ecbac2829a03d54850a2025-08-20T02:49:26ZengBMCMolecular Cancer1476-45982025-03-0124111710.1186/s12943-025-02298-7Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatmentSu Yin Lim0Suzanah C. Boyd1Russell J. Diefenbach2Helen Rizos3Faculty of Medicine, Health and Human Sciences, Macquarie UniversityFaculty of Medicine, Health and Human Sciences, Macquarie UniversityFaculty of Medicine, Health and Human Sciences, Macquarie UniversityFaculty of Medicine, Health and Human Sciences, Macquarie UniversityAbstract MicroRNAs (miRNAs) hold significant promise as circulating cancer biomarkers and unlike many other molecular markers, they can provide valuable insights that extend beyond tumour biology. The expression of circulating miRNAs may parallel the cellular composition and dynamic activity within the tumour microenvironment and reveal systemic immune responses. The functional complexity of miRNAs—where a single miRNA can regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, and a single mRNA can be targeted by multiple miRNAs—underscores their broad significance and impact. However, this complexity poses significant challenges for translating miRNA research into clinical practice. In melanoma, specific miRNA signatures have shown notable diagnostic, prognostic and predictive value, with lineage-specific and immune-related miRNAs frequently identified as valuable markers. In this review, we explore the role of circulating miRNAs as potential biomarkers in melanoma, and highlight the current status and advances required to translate miRNA research into therapeutic opportunities.https://doi.org/10.1186/s12943-025-02298-7MicroRNAMelanomaTreatment predictionBiomarkersImmune checkpoint inhibitorsTargeted therapies |
| spellingShingle | Su Yin Lim Suzanah C. Boyd Russell J. Diefenbach Helen Rizos Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment Molecular Cancer MicroRNA Melanoma Treatment prediction Biomarkers Immune checkpoint inhibitors Targeted therapies |
| title | Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment |
| title_full | Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment |
| title_fullStr | Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment |
| title_full_unstemmed | Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment |
| title_short | Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment |
| title_sort | circulating micrornas functional biomarkers for melanoma prognosis and treatment |
| topic | MicroRNA Melanoma Treatment prediction Biomarkers Immune checkpoint inhibitors Targeted therapies |
| url | https://doi.org/10.1186/s12943-025-02298-7 |
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