Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are critical conditions characterized by disruption of the alveolar-capillary barrier, uncontrolled inflammation, and progressive hypoxemia, with mortality rates exceeding 40 %. While conventional therapies such...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-10-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425007690 |
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| author | Yan Zhang Weiyao Sun Min Wang Yingying Qian Qing Zheng Wei Wang Heyu Yang Yansu Wang Mingjing Zhou Xianwen Wang Chun Yang |
| author_facet | Yan Zhang Weiyao Sun Min Wang Yingying Qian Qing Zheng Wei Wang Heyu Yang Yansu Wang Mingjing Zhou Xianwen Wang Chun Yang |
| author_sort | Yan Zhang |
| collection | DOAJ |
| description | Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are critical conditions characterized by disruption of the alveolar-capillary barrier, uncontrolled inflammation, and progressive hypoxemia, with mortality rates exceeding 40 %. While conventional therapies such as mechanical ventilation and glucocorticoids can partially alleviate symptoms, they face limitations, including low drug delivery efficiency, systemic toxicity, and inability to precisely regulate pathological microenvironments. Nanoparticles (NPs), which leverage their unique size effects, surface modifiability, and multifunctional integration capabilities, demonstrate advantages in targeted delivery, reduced systemic side effects, and multifunctional therapeutic potential and are emerging as novel tools to overcome current therapeutic bottlenecks. This review systematically summarizes the classification, mechanisms of action, and applications of NPs in ALI/ARDS treatment, while critically evaluating translational challenges and future development trajectories. |
| format | Article |
| id | doaj-art-78f849e42e4246d3a47900ba94d85e1e |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-78f849e42e4246d3a47900ba94d85e1e2025-08-25T04:14:40ZengElsevierMaterials Today Bio2590-00642025-10-013410219910.1016/j.mtbio.2025.102199Application of nanoparticles in the treatment of acute lung injury: Current situation and future directionsYan Zhang0Weiyao Sun1Min Wang2Yingying Qian3Qing Zheng4Wei Wang5Heyu Yang6Yansu Wang7Mingjing Zhou8Xianwen Wang9Chun Yang10School of Public Health, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaSchool of Public Health, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaCollege of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, ChinaSchool of Biomedical Engineering, Anhui Medical University, Hefei, 230032, China; Corresponding author.College of Basic Medicin, Beihua University, No. 3999 Binjiang East Road, Fengman District, Jilin City, Jilin Province, China; Corresponding author.Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), are critical conditions characterized by disruption of the alveolar-capillary barrier, uncontrolled inflammation, and progressive hypoxemia, with mortality rates exceeding 40 %. While conventional therapies such as mechanical ventilation and glucocorticoids can partially alleviate symptoms, they face limitations, including low drug delivery efficiency, systemic toxicity, and inability to precisely regulate pathological microenvironments. Nanoparticles (NPs), which leverage their unique size effects, surface modifiability, and multifunctional integration capabilities, demonstrate advantages in targeted delivery, reduced systemic side effects, and multifunctional therapeutic potential and are emerging as novel tools to overcome current therapeutic bottlenecks. This review systematically summarizes the classification, mechanisms of action, and applications of NPs in ALI/ARDS treatment, while critically evaluating translational challenges and future development trajectories.http://www.sciencedirect.com/science/article/pii/S2590006425007690ALINanoparticlesTargetedAnti-inflammatoryAntioxidantTissue regeneration |
| spellingShingle | Yan Zhang Weiyao Sun Min Wang Yingying Qian Qing Zheng Wei Wang Heyu Yang Yansu Wang Mingjing Zhou Xianwen Wang Chun Yang Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions Materials Today Bio ALI Nanoparticles Targeted Anti-inflammatory Antioxidant Tissue regeneration |
| title | Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions |
| title_full | Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions |
| title_fullStr | Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions |
| title_full_unstemmed | Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions |
| title_short | Application of nanoparticles in the treatment of acute lung injury: Current situation and future directions |
| title_sort | application of nanoparticles in the treatment of acute lung injury current situation and future directions |
| topic | ALI Nanoparticles Targeted Anti-inflammatory Antioxidant Tissue regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425007690 |
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