Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database
Abstract The published prevalence of essential tremor is variable worldwide and lacking in Central Europe. We aimed to estimate its prevalence in Hungary and to explore the locally applied therapeutic approaches. We collected data from the National Health Insurance Fund database and pharmacy databas...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-13145-6 |
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| author | Andrea Kinga Papp Ádám József Berki Péter Vinnai András Ajtay Dániel Bereczki Loránd Erőss Gertrúd Tamás |
| author_facet | Andrea Kinga Papp Ádám József Berki Péter Vinnai András Ajtay Dániel Bereczki Loránd Erőss Gertrúd Tamás |
| author_sort | Andrea Kinga Papp |
| collection | DOAJ |
| description | Abstract The published prevalence of essential tremor is variable worldwide and lacking in Central Europe. We aimed to estimate its prevalence in Hungary and to explore the locally applied therapeutic approaches. We collected data from the National Health Insurance Fund database and pharmacy database registered between 2010 and 2020. Matching the specified codes of the International Classification of Diseases and the individually tailored combination of interventions, we attempted to exclude Parkinson’s disease and other tremor evoking conditions. We estimated the period prevalence of essential tremor age standardized to the European Standard Population at 378–388/100,000. After excluding patients with possible Parkinsonian syndromes, we found that 36.4% of patients with tremor did not take any medication during the study period. Most of the rest used alprazolam followed by propranolol for the longest period of time; the alprazolam and propranolol combination was the most preferred. Deep brain stimulation and ablative surgery were chosen for less than 0.5% of the patients. Our strict methods probably underestimate the essential tremor prevalence in Hungary, which, however, does not differ considerably from international results. Given the limitations of medication therapy, expanding and improving neurosurgical interventions may help improve the quality of life of patients with essential tremor. |
| format | Article |
| id | doaj-art-78f24f5b105b489ea05d72f6037b34e1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-78f24f5b105b489ea05d72f6037b34e12025-08-20T04:02:45ZengNature PortfolioScientific Reports2045-23222025-08-0115111210.1038/s41598-025-13145-6Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund DatabaseAndrea Kinga Papp0Ádám József Berki1Péter Vinnai2András Ajtay3Dániel Bereczki4Loránd Erőss5Gertrúd Tamás6Department of Neurology, Semmelweis UniversityDepartment of Neurology, Semmelweis UniversityHUN-REN SU Neuroepidemiological Research GroupDepartment of Neurology, Semmelweis UniversityDepartment of Neurology, Semmelweis UniversityDepartment of Neurosurgery and Neurointervention, Semmelweis UniversityDepartment of Neurology, Semmelweis UniversityAbstract The published prevalence of essential tremor is variable worldwide and lacking in Central Europe. We aimed to estimate its prevalence in Hungary and to explore the locally applied therapeutic approaches. We collected data from the National Health Insurance Fund database and pharmacy database registered between 2010 and 2020. Matching the specified codes of the International Classification of Diseases and the individually tailored combination of interventions, we attempted to exclude Parkinson’s disease and other tremor evoking conditions. We estimated the period prevalence of essential tremor age standardized to the European Standard Population at 378–388/100,000. After excluding patients with possible Parkinsonian syndromes, we found that 36.4% of patients with tremor did not take any medication during the study period. Most of the rest used alprazolam followed by propranolol for the longest period of time; the alprazolam and propranolol combination was the most preferred. Deep brain stimulation and ablative surgery were chosen for less than 0.5% of the patients. Our strict methods probably underestimate the essential tremor prevalence in Hungary, which, however, does not differ considerably from international results. Given the limitations of medication therapy, expanding and improving neurosurgical interventions may help improve the quality of life of patients with essential tremor.https://doi.org/10.1038/s41598-025-13145-6EpidemiologyEssential tremorHungaryPrevalenceTherapyTremor |
| spellingShingle | Andrea Kinga Papp Ádám József Berki Péter Vinnai András Ajtay Dániel Bereczki Loránd Erőss Gertrúd Tamás Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database Scientific Reports Epidemiology Essential tremor Hungary Prevalence Therapy Tremor |
| title | Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database |
| title_full | Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database |
| title_fullStr | Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database |
| title_full_unstemmed | Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database |
| title_short | Prevalence estimation of essential tremor in Hungary between 2010 and 2020 based on the National Health Insurance Fund Database |
| title_sort | prevalence estimation of essential tremor in hungary between 2010 and 2020 based on the national health insurance fund database |
| topic | Epidemiology Essential tremor Hungary Prevalence Therapy Tremor |
| url | https://doi.org/10.1038/s41598-025-13145-6 |
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