Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival

Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain hig...

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Main Authors: K. E. O’Sullivan, E. T. Hurley, J. P. Hurley
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Gastroenterology Research and Practice
Online Access:http://dx.doi.org/10.1155/2015/518281
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author K. E. O’Sullivan
E. T. Hurley
J. P. Hurley
author_facet K. E. O’Sullivan
E. T. Hurley
J. P. Hurley
author_sort K. E. O’Sullivan
collection DOAJ
description Despite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.
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institution Kabale University
issn 1687-6121
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language English
publishDate 2015-01-01
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series Gastroenterology Research and Practice
spelling doaj-art-78f12859d3764da290286fc92f7f20232025-02-03T01:30:37ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/518281518281Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and SurvivalK. E. O’Sullivan0E. T. Hurley1J. P. Hurley2The Mater Private Hospital, Eccles Street, Dublin, IrelandThe Mater Private Hospital, Eccles Street, Dublin, IrelandThe Mater Private Hospital, Eccles Street, Dublin, IrelandDespite significant improvement over recent decades, oesophageal cancer survival rates remain poor. Neoadjuvant chemoradiotherapy followed by oesophageal resection is mainstay of therapy for resectable oesophageal tumours. Operative morbidity and mortality associated with oesophagectomy remain high and complications arise in up to 60% of patients. Management strategies have moved towards definitive chemoradiotherapy for a number of tumour sites (head and neck, cervical, and rectal) particularly for squamous pathology. We undertook to perform a review of the current status of morbidity and mortality associated with oesophagectomy, grading systems determining pathologic response, and data from clinical trials managing patients with definitive chemoradiotherapy to inform a discussion on the topic.http://dx.doi.org/10.1155/2015/518281
spellingShingle K. E. O’Sullivan
E. T. Hurley
J. P. Hurley
Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
Gastroenterology Research and Practice
title Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_full Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_fullStr Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_full_unstemmed Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_short Understanding Complete Pathologic Response in Oesophageal Cancer: Implications for Management and Survival
title_sort understanding complete pathologic response in oesophageal cancer implications for management and survival
url http://dx.doi.org/10.1155/2015/518281
work_keys_str_mv AT keosullivan understandingcompletepathologicresponseinoesophagealcancerimplicationsformanagementandsurvival
AT ethurley understandingcompletepathologicresponseinoesophagealcancerimplicationsformanagementandsurvival
AT jphurley understandingcompletepathologicresponseinoesophagealcancerimplicationsformanagementandsurvival