Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia
Background: This study aimed to investigate serum levels of calcitonin gene-related peptide (CGRP) and explore potential associations between serum CGRP, adiponectin, and ghrelin concentrations in patients with preeclampsia. Metho...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG26556 |
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| author | Özlem Koşar Can Umit Cabus Cihan Kabukcu Semin Fenkci Veysel Fenkci Yasar Enli |
| author_facet | Özlem Koşar Can Umit Cabus Cihan Kabukcu Semin Fenkci Veysel Fenkci Yasar Enli |
| author_sort | Özlem Koşar Can |
| collection | DOAJ |
| description | Background: This study aimed to investigate serum levels of calcitonin gene-related peptide (CGRP) and explore potential associations between serum CGRP, adiponectin, and ghrelin concentrations in patients with preeclampsia. Methods: This study evaluated 43 normotensive healthy pregnant women and 36 pregnant women diagnosed with preeclampsia. Serum concentrations of CGRP, adiponectin, and ghrelin were measured in both groups during the third trimester of pregnancy. Results: Serum concentrations of CGRP were significantly elevated in the preeclampsia group compared to the control group. Conversely, the preeclampsia group exhibited significantly decreased serum levels of adiponectin and ghrelin relative to the controls. No significant correlation was observed between serum CGRP levels and adiponectin or ghrelin levels in either the preeclampsia or control groups. Conclusions: Our study demonstrates a considerable increase in serum CGRP concentrations in patients with preeclampsia compared to the control group. These outcomes strongly indicate that CGRP may play a pivotal role in the pathogenesis of preeclampsia. |
| format | Article |
| id | doaj-art-78f09b6e324e4879bdf890c2caebcbec |
| institution | DOAJ |
| issn | 0390-6663 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-78f09b6e324e4879bdf890c2caebcbec2025-08-20T02:43:38ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632025-06-015262655610.31083/CEOG26556S0390-6663(25)02590-4Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on PreeclampsiaÖzlem Koşar Can0Umit Cabus1Cihan Kabukcu2Semin Fenkci3Veysel Fenkci4Yasar Enli5Department of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyDepartment of Obstetrics and Gynecology, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyDepartment of Biochemistry, Faculty of Medicine, Pamukkale University, 20070 Denizli, TurkeyBackground: This study aimed to investigate serum levels of calcitonin gene-related peptide (CGRP) and explore potential associations between serum CGRP, adiponectin, and ghrelin concentrations in patients with preeclampsia. Methods: This study evaluated 43 normotensive healthy pregnant women and 36 pregnant women diagnosed with preeclampsia. Serum concentrations of CGRP, adiponectin, and ghrelin were measured in both groups during the third trimester of pregnancy. Results: Serum concentrations of CGRP were significantly elevated in the preeclampsia group compared to the control group. Conversely, the preeclampsia group exhibited significantly decreased serum levels of adiponectin and ghrelin relative to the controls. No significant correlation was observed between serum CGRP levels and adiponectin or ghrelin levels in either the preeclampsia or control groups. Conclusions: Our study demonstrates a considerable increase in serum CGRP concentrations in patients with preeclampsia compared to the control group. These outcomes strongly indicate that CGRP may play a pivotal role in the pathogenesis of preeclampsia.https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG26556preeclampsiacalcitonin gene-related peptideghrelinadiponectin |
| spellingShingle | Özlem Koşar Can Umit Cabus Cihan Kabukcu Semin Fenkci Veysel Fenkci Yasar Enli Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia Clinical and Experimental Obstetrics & Gynecology preeclampsia calcitonin gene-related peptide ghrelin adiponectin |
| title | Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia |
| title_full | Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia |
| title_fullStr | Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia |
| title_full_unstemmed | Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia |
| title_short | Variations in Calcitonin Gene-Related Peptide, Adiponectin, and Ghrelin Levels and Their Effects on Preeclampsia |
| title_sort | variations in calcitonin gene related peptide adiponectin and ghrelin levels and their effects on preeclampsia |
| topic | preeclampsia calcitonin gene-related peptide ghrelin adiponectin |
| url | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG26556 |
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