GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation

GLP-1 and its derived peptides mediate pain relief through direct TRPV1 inhibition without affecting thermoregulation

Abstract Hormonal regulation during food ingestion and its association with pain prompted the investigation of the impact of glucagon-like peptide-1 (GLP-1) on transient receptor potential vanilloid 1 (TRPV1). Both endogenous and synthetic GLP-1, as well as a GLP-1R antagonist, exendin 9–39, reduced...

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Main Authors: Eun Jin Go, Sung-Min Hwang, Hyunjung Jo, Md. Mahbubur Rahman, Jaeik Park, Ji Yeon Lee, Youn Yi Jo, Byung-Gil Lee, YunJae Jung, Temugin Berta, Yong Ho Kim, Chul-Kyu Park
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-024-01342-8
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