Correlation between traumatic brain injury, obesity and insulin-resistance – a case report
Introduction: Traumatic brain injury is a significant global health concern. It often results from high-velocity accidents and leads to diffuse axonal injury, causing consciousness disorders and potentially permanent cognitive and behavioural changes. Individuals with traumatic brain injury often ex...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2025-02-01
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| Series: | Journal of Rehabilitation Medicine - Clinical Communications |
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| Online Access: | https://medicaljournalssweden.se/jrm-cc/article/view/36827 |
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| author | Laura De Wilde Charlotte De Ruysscher Kristine Oostra |
| author_facet | Laura De Wilde Charlotte De Ruysscher Kristine Oostra |
| author_sort | Laura De Wilde |
| collection | DOAJ |
| description | Introduction: Traumatic brain injury is a significant global health concern. It often results from high-velocity accidents and leads to diffuse axonal injury, causing consciousness disorders and potentially permanent cognitive and behavioural changes. Individuals with traumatic brain injury often exhibit weight gain, potentially leading to obesity. This weight increase is influenced by cognitive dysfunction, reduced physical activity and metabolic changes.
Case report: A 23-year-old woman suffered a traumatic brain injury after a traffic accident, with an initial Glasgow Coma Scale score of 5/15. Positive neurological improvement was observed during her stay in the intensive care unit and the neurosurgical department. Subsequently, she was transferred to the rehabilitation department, where she faced significant challenges, including mood fluctuations, cognitive impairments and substantial weight gain. Her body mass index (BMI) increased from 23 kg/m2 pre-accident to a maximum of 36 kg/m2, despite interventions like medications and lifestyle changes. Blood tests revealed insulin-resistance and metformin initiated a successful weight reduction.
Conclusion: Managing weight gain following traumatic brain injury requires effective interventions that acknowledge its complexity and multifaceted nature, including lifestyle modifications, behavioural therapy and potentially pharmacotherapy or bariatric surgery. Further research is essential to better understand underlying mechanisms and evaluate intervention effectiveness in this specific patient population.
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| format | Article |
| id | doaj-art-78ed91a4b45141caa0497526103b62cf |
| institution | Kabale University |
| issn | 2003-0711 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Journal of Rehabilitation Medicine - Clinical Communications |
| spelling | doaj-art-78ed91a4b45141caa0497526103b62cf2025-02-03T08:35:30ZengMedical Journals SwedenJournal of Rehabilitation Medicine - Clinical Communications2003-07112025-02-01810.2340/jrm-cc.v8.36827Correlation between traumatic brain injury, obesity and insulin-resistance – a case reportLaura De Wilde0Charlotte De Ruysscher1Kristine Oostra2Faculty of Medicine, Ghent University, Ghent, Belgium; Department of Physical and Rehabilitation Medicine, Ghent University Hospital, Ghent, BelgiumDepartment of Physical Medicine and Rehabilitation, University Hospital Brussels, Brussels, Belgium.Department of Physical and Rehabilitation Medicine, Ghent University Hospital, Ghent, Belgium.Introduction: Traumatic brain injury is a significant global health concern. It often results from high-velocity accidents and leads to diffuse axonal injury, causing consciousness disorders and potentially permanent cognitive and behavioural changes. Individuals with traumatic brain injury often exhibit weight gain, potentially leading to obesity. This weight increase is influenced by cognitive dysfunction, reduced physical activity and metabolic changes. Case report: A 23-year-old woman suffered a traumatic brain injury after a traffic accident, with an initial Glasgow Coma Scale score of 5/15. Positive neurological improvement was observed during her stay in the intensive care unit and the neurosurgical department. Subsequently, she was transferred to the rehabilitation department, where she faced significant challenges, including mood fluctuations, cognitive impairments and substantial weight gain. Her body mass index (BMI) increased from 23 kg/m2 pre-accident to a maximum of 36 kg/m2, despite interventions like medications and lifestyle changes. Blood tests revealed insulin-resistance and metformin initiated a successful weight reduction. Conclusion: Managing weight gain following traumatic brain injury requires effective interventions that acknowledge its complexity and multifaceted nature, including lifestyle modifications, behavioural therapy and potentially pharmacotherapy or bariatric surgery. Further research is essential to better understand underlying mechanisms and evaluate intervention effectiveness in this specific patient population. https://medicaljournalssweden.se/jrm-cc/article/view/36827Brain Injuries, TraumaticCognitive DysfunctionDiffuse Axonal InjuryExerciseInsulin ResistanceMetabolic Diseases |
| spellingShingle | Laura De Wilde Charlotte De Ruysscher Kristine Oostra Correlation between traumatic brain injury, obesity and insulin-resistance – a case report Journal of Rehabilitation Medicine - Clinical Communications Brain Injuries, Traumatic Cognitive Dysfunction Diffuse Axonal Injury Exercise Insulin Resistance Metabolic Diseases |
| title | Correlation between traumatic brain injury, obesity and insulin-resistance – a case report |
| title_full | Correlation between traumatic brain injury, obesity and insulin-resistance – a case report |
| title_fullStr | Correlation between traumatic brain injury, obesity and insulin-resistance – a case report |
| title_full_unstemmed | Correlation between traumatic brain injury, obesity and insulin-resistance – a case report |
| title_short | Correlation between traumatic brain injury, obesity and insulin-resistance – a case report |
| title_sort | correlation between traumatic brain injury obesity and insulin resistance a case report |
| topic | Brain Injuries, Traumatic Cognitive Dysfunction Diffuse Axonal Injury Exercise Insulin Resistance Metabolic Diseases |
| url | https://medicaljournalssweden.se/jrm-cc/article/view/36827 |
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